400024-08-0

Basic information

• Product Name: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester
• CAS NO: 400024-08-0
• Molecular Formula: C23H20ClNO6
• Molecular Weight: 441.868
• Mol File: 400024-08-0.mol

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester(400024-08-0)
• EPA Substance Registry System: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester(400024-08-0)

Safety Data

• Hazardous Substances Data: 400024-08-0(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 1074-82-4 potassium phtalimide 
• 13176-46-0 4-bromoethyl acetoacetate 

Downstream Products

• 223734-99-4 ethylmethyl-2,6-bis-[(2-phthalimidoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 88150-62-3 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-phthalimidoethoxymethyl]-1,4-dihydropyridine 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

Synthesis process of amlodipine besylate

The invention discloses a synthesis process of amlodipine besylate, relates to the technical field of medicine synthesis and solves the problems of low product purity and poor product quality controllability of products prepared by the existing synthesis process. According to the synthesis process, phthalic anhydride is used as raw materials; the parameters of the synthesis process are controlled;the technical flow process is shortened; the synthesis cost is reduced; the product yield is as high as 91 percent; the purity of the prepared amlodipine besylate is as high as 99.5 percent. The self-made amlodipine besylate are used as raw materials for further preparing the amlodipine besylate tablets; the product cost is reduced; the product quality controllability is high.

ISOLATION OF DIHYDROPYRIDINE DERIVATIVE AND PREPARATION SALTS THEREOF

The title compound is isolated in pure form by using a crystallization process and converted to its pharmaceutically acceptable salts. The crystallization process affects stability and purity of the amlodipine salts. All known impurities and one unknown impurity, which forms during the synthesis of the amlodipine salts, were isolated, characterized, and synthesized. A new method allowing the quantitative HPLC analysis of all related impurities of amlodipine salts in a single chromatogram was developed.