400053-10-3

Upstream product

• 104-94-9 4-methoxy-aniline 
• 400604-97-9 N³,N³-(3-oxapentan-1,5-diyl)-N¹-(2-phenyl-3,4-dihydroquinazolin-4-yliden)thiourea 

Downstream Products

• 1022-44-2 4-amino-2-phenyl-quinazoline 
• 1227-45-8 1,3-bis-(p-methoxyphenyl)thiourea 

Relevant academic research and scientific papers

One-pot quinazolin-4-yl-thiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate

1-substituted-3-(2-phenylquinazolin-4-yl) thioureas (7) were produced by an intramolecular cycloaddition reaction of 1-substitued-3-[(2-cyanophenylimino) phenylmethyl] thioureas (3). These compounds in turn were prepared by the reaction of N-(2-cyanophenyl)benzimidoyl isothiocyanate (2) with primary amines. The structures of products 7 were confirmed by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and X-ray crystallography.

Reactivity study on morpholine-1-carbothioic acid (2-phenyl-3H-quinazolin-4-ylidene) amide

Regioselective reactions of morpholine-1-carbothioic acid (2-phenyl-3H-quinazolin-4-ylidene) amide (1) with electrophiles and nucleophiles were studied. The compound (1) reacts with alkyl halides in basic medium to afford S-substituted isothiourea derivat