1227-45-8

Basic information

• Product Name: 1,3-bis(4-methoxyphenyl)thiourea
• Synonyms: 1,3-bis(4-methoxyphenyl)thiourea;1,3-Bis(p-methoxyphenyl)thiourea;4,4'-DIMETHOXYTHIOCARBANILIDE
• CAS NO: 1227-45-8
• Molecular Formula: C₁₅H₁₆N₂O₂S
• Molecular Weight: 288.3647
• Mol File: 1227-45-8.mol
• Article Data: 40

Chemical Properties

• Melting Point: 185.0 to 189.0 °C
• Boiling Point: 421.9°Cat760mmHg
• Flash Point: 209°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 2.51E-07mmHg at 25°C
• Refractive Index: 1.683
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.10±0.70(Predicted)
• CAS DataBase Reference: 1,3-bis(4-methoxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(4-methoxyphenyl)thiourea(1227-45-8)
• EPA Substance Registry System: 1,3-bis(4-methoxyphenyl)thiourea(1227-45-8)

Safety Data

• RTECS: YS2750000
• Hazardous Substances Data: 1227-45-8(Hazardous Substances Data)

Usage

Description

1,3-bis(4-methoxyphenyl)thiourea is a chemical compound characterized by a thiourea core, which is an organic compound with two amine functional groups (-NH2) adjacent to a carbonyl group (C=O). The amine groups in this compound are substituted with methoxyphenyl groups, which are phenyl rings (a type of benzene ring) that include a methoxy group (-OCH3). This structural feature suggests that the compound could serve as a potential ligand for various metal ions and may possess properties such as antimicrobial activity or distinctive optical characteristics.

Uses

1. Used in Chemical Research:
1,3-bis(4-methoxyphenyl)thiourea is used as a research compound for exploring its interactions with metal ions and other molecules, due to its thiourea core and methoxyphenyl groups.
2. Used in Pharmaceutical Development:
1,3-bis(4-methoxyphenyl)thiourea is used as a potential candidate in drug discovery, leveraging its structural properties to develop new therapeutic agents, particularly if its antimicrobial activities or other biological effects are confirmed.
3. Used in Material Science:
1,3-bis(4-methoxyphenyl)thiourea is used as a component in the development of new materials, possibly taking advantage of its optical properties or its ability to form complexes with metal ions for applications in areas such as sensors or catalysts.
Note: The specific uses mentioned are hypothetical and based on the potential properties of the compound as described. The actual applications may vary and would require further research and development to confirm.

InChI:InChI=1/C15H16N2O2S/c1-18-13-7-3-11(4-8-13)16-15(20)17-12-5-9-14(19-2)10-6-12/h3-10H,1-2H3,(H2,16,17,20)

Upstream product

• 56-23-5 tetrachloromethane 
• 104-94-9 4-methoxy-aniline 
• 1219-96-1 N-(p-methoxyphenyl)-N'-phenylthiourea 
• 102-08-9 N,N-diphenylthiourea 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 103-72-0 phenyl isothiocyanate 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 4314-19-6 bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione 
• 94793-46-1 N-(4-Methoxy-phenyl)-formamidine 
• 2293-07-4 (4-methoxy-phenyl)-thiourea 
• 20265-97-8 p-anisidine hydrochloride 
• 624-84-0 formic acid hydrazide 
• 17356-08-0 thiourea 
• 400053-10-3 1-(4-methoxyphenyl)-3-(2-phenylquinazolin-4-yl) thiourea 

Downstream Products

• 23808-76-6 [4-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-3H-thiazol-2-ylidene]-(4-methoxy-phenyl)-amine 
• 103989-18-0 3-(4-methoxy-phenyl)-5-methyl-thiazolidine-2,4-dione 
• 13715-74-7 N-(4-ethoxy-phenyl)-N',N''-bis-(4-methoxy-phenyl)-guanidine 
• 855760-40-6 (4-methoxy-phenyl)-(6-methoxy-2-phenyl-[4]quinolyl)-amine 
• 39139-62-3 3-(4-methoxyphenyl)-2-(4-methoxyphenylimino)-1,3-thiazolidine-4-one 
• 32826-88-3 3-(4-methoxyphenyl)-1,3-thiazolidine-2,4-dione 
• 1848-63-1 (4,5-dihydro-oxazol-2-yl)-(4-methoxy-phenyl)-amine 
• 104-94-9 4-methoxy-aniline 
• 90731-05-8 N,N-dimethyl-N′,N″-bis(4-methoxyphenyl)guanidine 
• 1421969-86-9 N,N-dimethyl-N′,N″-bis(4-methoxyphenyl)guanidinium iodide 
• 73565-26-1 N,1-bis(4-methoxyphenyl)-1H-tetrazol-5-amine 

Relevant articles and documents

Chemistry of phosphorus ylides: Part 45 synthesis of phosphoranylidene, thietane, azetidine and thiazinane derivatives as potent chemo preventative agents

Reactions of nucleophilic active phosphacumulenes with iso(thio)cyanate compounds were performed. The reaction products depend on the nature of the reagent, substrate and the condition of the reaction used. New heterocyclic 4-membered or 6-membered sulfur

Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water

ABATRACT: A direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.

A facile method for the preparation of carbodiimides from thioureas and (Boc)2O

A concise method for the preparation of carbodiimides from thioureas using di-tert-butyl dicarbonate [(Boc)2O] as the dehydrosulfurizative reagent has been developed. Using DMAP as the catalyst, a variety of symmetric and asymmetric 1,3-diaryl thioureas were converted into the corresponding carbodiimides efficiently in a short time.