400073-81-6

Basic information

• Product Name: 2'-AMINO-4-TRIFLUOROMETHYLBENZANILIDE
• Synonyms: 2'-AMINO-4-TRIFLUOROMETHYLBENZANILIDE;N-(2-AMINOPHENYL)-4-(TRIFLUOROMETHYL)BENZAMIDE;2-{[4-(Trifluoromethyl)benzoyl]amino}aniline;OTAVA-BB 1173297;Benzamide, N-(2-aminophenyl)-4-trifluoromethyl-
• CAS NO: 400073-81-6
• Molecular Formula: C₁₄H₁₁F₃N₂O
• Molecular Weight: 280.25
• Mol File: 400073-81-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-AMINO-4-TRIFLUOROMETHYLBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-AMINO-4-TRIFLUOROMETHYLBENZANILIDE(400073-81-6)
• EPA Substance Registry System: 2'-AMINO-4-TRIFLUOROMETHYLBENZANILIDE(400073-81-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 400073-81-6(Hazardous Substances Data)

Usage

Functional Groups

Amine group (NH2)
Trifluoromethyl group (CF3)
Benzene ring

Applications

Pharmaceutical Industry:
Building block for synthesizing various drugs and pharmaceutical compounds.
Organic Chemistry:
Used as a reagent in organic chemistry reactions.
Biomedical Research:
Utilized as a research tool in biomedical research.

Safety Considerations

Potentially Hazardous:
Should be handled with caution due to its hazardous nature.

Upstream product

• 161266-16-6 N-(2-nitrophenyl)-4-trifluoromethylbenzamide 
• 1173706-99-4 N-(2-iodophenyl)-4-(trifluoromethyl)benzamide 
• 1017041-20-1 C₁₄H₉BrF₃NO 

Relevant articles and documents

Copper-catalyzed regioselective 2-amination of o-haloanilides with aqueous ammonia

An efficient Cu(II)-vasicine catalytic system has been developed for intramolecular C[sbnd]N bond formation. In this way, regioselective 2-amination of o-haloanilides with aqueous ammonia in EtOH has been achieved. This strategy provides several advantages, such as good regioselectivity, high yields and functional group tolerance.

Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. Design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor

Although cyclooxygenase-1 (COX-1) inhibition is thought to be a major mechanism of gastric damage by nonsteroidal anti-inflammatory drugs (NSAIDs), some COX-1-selective inhibitors exhibit strong analgesic effects without causing gastric damage. However, it is not clear whether their analgesic effects are attributable to COX-1-inhibitory activity or other bioactivities. Here, we report that N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)benzamide (18f, TFAP), which has a structure clearly different from those of currently available COX-1-selective inhibitors, is a potent COX-1-selective inhibitor (COX-1 IC 50 = 0.80 ± 0.05 μM, COX-2 IC50 = 210 ± 10 μM). This compound causes little gastric damage in rats even at an oral dose of 300 mg/kg, though it has an analgesic effect at as low a dose as 10 mg/kg. Our results show that COX-1-selective inhibitors can be analgesic agents without causing gastric damage.