40026-24-2

Usage

Uses

Used in Pharmaceutical Industry:
2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydrois used as a therapeutic agent for its potential effects on a range of health conditions, including cancer, diabetes, and neurodegenerative diseases. Its ability to modulate immune responses and inflammatory pathways contributes to its potential as a treatment option.
Used in Antiviral Applications:
2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydrois used as an antiviral agent, particularly as a potential inhibitor of the hepatitis C virus. Its anti-viral properties highlight its potential in developing treatments for viral infections.

Upstream product

• 52011-76-4 6-chloro-4-oxo-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 357396-06-6 (+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates

Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2′-hydroxy)phenylbutanoates derived from l-malic acid.

Fused bicyclic carboxamide derivatives and methods of their use

Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.

Lipase-mediated kinetic resolution of rigid clofibrate analogues with lipid-modifying activity

The lipase-catalysed kinetic resolution of methyl esters of (±)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acid, (±)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid, and (±)-6-chloro-2,3-dihydro-4H-1-benzopyran-3-carboxylic acid, rigid analogues of clofibrate, was effected with fair to moderate enantioselectivities (E = 1.0-4.8), enantiomeric excesses of up to 86% and workable reaction rates. Enantiomerically pure (R)- and (S)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acids were obtained by fractional crystallisation of the diastereomeric salts of the corresponding racemic acid with (+)- and (-)-amphetamine from ethanol; the absolute configuration of the products were established by chemical correlation.

6-Chloro-2,3-Dihydro-4H-1-Benzopyran Carboxylic Acids: Synthesis, Optical Resolution and Absolute Configuration

6-Chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid, a rigid analogue of clofibric acid, the active metabolite of the antilipidemic drug clofibrate, has been prepared together with two isomers, 6-chloro-2,3-dihydro-4H-1-benzopyran-3- and 4-carboxylic a