40052-63-9

Usage

Uses

Used in Mathematical Calculations:
0 is used as a placeholder in the decimal number system for [application reason] facilitating the representation of numbers and performing arithmetic operations.
Used in Computer Science:
0 is used as a binary digit in computer systems for [application reason] representing the off state in electronic circuits and serving as a base for binary arithmetic.
Used in Engineering and Physics:
0 is used as a reference point in engineering and physics for [application reason] establishing a baseline from which measurements and calculations are made.
Used in Chemistry:
0 is used as a pH value in chemistry for [application reason] indicating a neutral solution, neither acidic nor basic.
Used in Medicine:
0 is used as a reference value in medical measurements for [application reason] providing a baseline for assessing changes in a patient's condition.
Used in 2-Bromo-N-methylethanamine Hydrobromide Application:
In the context of 2-Bromo-N-methylethanamine Hydrobromide, 0 is used as a reference value for [application reason] preparing a high-strength alkaline anionic polymer crosslinked membrane, where it may represent the starting point or the null value in the process.

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 

Downstream Products

• 131636-36-7 phenyl N-methyl-N-(2-bromoethyl)phosphoramidate chloride 
• 1072-44-2 N-methylaziridine 
• 838892-92-5 [2-(4-fluorophenylsulfanyl)ethyl]methylamine 
• 743460-48-2 biphenyl-2-ylcarbamic acid 1-[2-(methylamino)ethyl]piperidin-4-yl ester 
• 312719-46-3 tetrahydrofurfuryl benzyl N-methyl-N-(2-bromoethyl)phosphoramidate 
• 80754-84-3 benzyl N-(2-bromoethyl)-N-methylcarbamate 

Relevant academic research and scientific papers

The synthetic tuning of clickable pH responsive cationic polypeptides and block copolypeptides

A series of pH responsive synthetic polypeptides has been developed based on an N-carboxyanhydride ring opening polymerization combined with a facile and versatile click chemistry. Poly(γ-propargyl l-glutamate) (PPLG) homopolymers and poly(ethylene glycol-b-γ-propargyl l-glutamate) (PEG-b-PPLG) block copolymers were substituted with various amine moieties that range in pKa and hydrophobicity, providing the basis for a library of new synthetic structures that can be tuned for specific interactions and responsive behaviors. These amine-functionalized polypeptides have the ability to change solubility, or reversibly self-assemble into micelles with changes in the degree of ionization; they also adopt an α-helical structure at biologically relevant pHs. Here we characterize the pH responsive behavior of the new polypeptides and the hydrolysis of the ester containing amine side chains. We examine the reversible micellization with block copolymers of the polypeptides and nucleic acid encapsulation that demonstrate the potential use of these materials for systemic drug and gene delivery.

Molecular recognition on a cavitand-functionalized silicon surface

A Si(100) surface featuring molecular recognition properties was obtained by covalent functionalization with a tetraphosphonate cavitand (Tiiii), able to complex positively charged species. Tiiii cavitand was grafted onto the Si by photochemical hydrosily

Radical cage effects in the photochemical degradation of polymers: Effect of radical size and mass on the cage recombination efficiency of radical cage pairs generated photochemically from the (CpCH2CH 2N(CH3)C(O)(CH2)nCH 3)2Mo2(CO)6 (n = 3, 8, 18) complexes

This study explored the effect of radical size, chain length, and mass on the cage recombination efficiency of photochemically generated radical cage pairs. Radical cage pairs containing long-chain radicals of the type [(CpCH 2CH2N(CH3)C(O)(CH2) nCH3)(CO)3Mo?, ?Mo(CO)3(CpCH 2CH2(CH3)NC(O)(CH2) nCH3)] were generated in hexanes/squalane solution by photolysis (λ = 546 nm) of the Mo-Mo bonds in (CpCH2CH 2N-(CH3)C(O)(CH2)nCH 3)2Mo2(CO)6 (n = 3, 8, 18). The cage recombination efficiencies (denoted as FcP, where F cP = kcP/(kcp + kdP), k dP is the diffusion rate constant, and kcP is the radical recombination rate constant) for the radical cage pairs were obtained by extracting them from quantum yield measurements for the photoreactions with CCl4 (a metal-radical trap) as a function of solvent system viscosity. The results show that FcP increases as the length of the chain on a radical center increases. This finding likely provides at least one of the reasons why the quantum yields for photolytic polymer degradation (and long-chain molecules, in general) decrease as the polymer chains get longer. In quantitative terms, plots of kdP/kcP were linearly proportional to mass1/2/radius2, in agreement with the prediction of Noyes' cage effect theory. The "radius" of a long-chain radical, such as those studied herein, is rather vague, and for that reason a less ambiguous structural parameter was sought to replace the r2 term in the Noyes expression. Plots of kdP/kcP vs mass1/2/surface area suggest that surface area can be used in place of the radius2 term in the Noyes expression. The significance of being able to use a particle's surface area in the Noyes expression is that the expression becomes useful for nonspherical particles. The new expression allows the approximate prediction of FcP values for radicals of different sizes and masses.

A Bifunctional Copper Catalyst Enables Ester Reduction with H2: Expanding the Reactivity Space of Nucleophilic Copper Hydrides

Employing a bifunctional catalyst based on a copper(I)/NHC complex and a guanidine organocatalyst, catalytic ester reductions to alcohols with H2 as terminal reducing agent are facilitated. The approach taken here enables the simultaneous activation of esters through hydrogen bonding and formation of nucleophilic copper(I) hydrides from H2, resulting in a catalytic hydride transfer to esters. The reduction step is further facilitated by a proton shuttle mediated by the guanidinium subunit. This bifunctional approach to ester reductions for the first time shifts the reactivity of generally considered "soft"copper(I) hydrides to previously unreactive "hard"ester electrophiles and paves the way for a replacement of stoichiometric reducing agents by a catalyst and H2.

A new water soluble copper N-heterocyclic carbene complex delivers mild O6G-selective RNA alkylation

We show here that copper carbenes generated from diazo acetamides alkylate single RNAs, mRNAs, or pools of total transcriptome RNA, delivering exclusively alkylation at the O6 position in guanine (O6G). Although the reaction is effective with free copper some RNA fragmentation occurs, a problem we resolve by developing a novel water-stable copper N-heterocyclic carbene complex. Carboxymethyl adducts at O6G are known mutagenic lesions in DNA but their relevance in RNA biochemistry is unknown. As a case-in-point we re-examine an old controversy regarding whether O6G damage in RNA is susceptible to direct RNA repair.

NOVEL INTERMEDIATES FOR CYCLOPENTADIENYL DERIVATIVES AND PREPARATION METHOD OF SAID CYCLOPENTADIENYL DERIVATIVES

The present invention relates to a novel cyclopentadienyl-ethyl-methylamine (CpEMA) oxalate of chemical formula 1, or cyclopentadienyl-propyl-methylamine (CpPMA) oxalate of chemical formula 2, which is an intermediate for preparing CpEMA of chemical formula 3, and CpPMA of chemical formula 4 forming a metal precursor used for a self-limiting reaction used for an atomic layer deposition (ALD) or chemical vapor deposition process, and to a method for preparing a compound of chemical formula 3 and a compound of chemical formula 4 by using the compound of chemical formula 1 or 2 as an intermediate. According to the present invention, provided is a method for conveniently and easily preparing, in a high purity, a cyclopentadienyl derivative forming a precursor used for a self-limiting reaction among precursors used for an ALD or chemical vapor deposition process by using a novel intermediate.COPYRIGHT KIPO 2018

Development of a chiral bis(guanidino)iminophosphorane as an uncharged organosuperbase for the enantioselective amination of ketones

Chiral bis(guanidino)iminophosphoranes were designed and synthesized as chiral uncharged organosuperbase catalysts that facilitate activation of less-acidic pro-nucleophiles. The newly developed bis(guanidino) iminophosphoranes, which possess the highest basicity among chiral organocatalysts reported to date, were proven to be a superb class of chiral organosuperbases by reaction of azodicarboxylates with 2-alkyltetralones and their analogues as the less acidic pro-nucleophiles.

Amine-linked N-heterocyclic carbenes: The importance of an pendant free-amine auxiliary in assisting the catalytic reaction

We have successfully expanded the library of amino-NHCs with varying substituents on the amine group, leading to insight about the instability of NHCs arising from the intermolecular interaction of the dangling amine side-arm. However, the pendant amine plays an important role with respect to the catalytic process, resuscitating the catalytic activity of unsaturated NHC's through a synergistic effect invoked by the secondary amine. This proof of concept allows us to expand the spectrum of catalysis to C-C, as well as C-B bond formation. Copyright

Phosphoramidate analogs of 2'-deoxyuridine

The present invention provides a series of cytotoxic phosphoramidate analogs of 5-fluoro-2'-deoxyuridine of the general formula (I): STR1 wherein R1 is H, F or (C1 -C4)alkyl; R2 is CH2 CH2 X wherein X is Cl, Br, I or p-toluenesulfonyl; R3 is (C1 -C4)alkyl or CH2 CH2 X wherein X is Cl, Br, I or p-toluenesulfonyl; or wherein R2 and R3, taken together with the N atom, can be a 5- or 6-membered heterocyclic ring which is aliphatic or aliphatic interrupted by a ring oxygen or a second ring nitrogen; R4 is H, one equivalent of a pharmaceutically-acceptable cation or (4,4,6-trimethyltetrahydro-1,3-oxazin-2-yl)ethyl, and the pharmaceutically-acceptable salts thereof.