400608-30-2

Basic information

• Product Name: 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBE&
• Synonyms: 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBE&;1-trimethylsilylethynyl-3,5-dimethoxyben;3,5-dimethoxy-1-(trimethylsilylethynyl)benzene;1-trimethylsilylethynyl-3;3,5-Dimethoxy-1-(trimethylsilylethynyl)benzene, [(3,5-Dimethoxyphenyl)ethynyl]trimethylsilane
• CAS NO: 400608-30-2
• Molecular Formula: C₁₃H₁₈O₂Si
• Molecular Weight: 234.37
• Mol File: 400608-30-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 61-65 °C(lit.)
• Boiling Point: 300.4°C at 760 mmHg
• Flash Point: 106°C
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 0.00201mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBE&(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBE&(400608-30-2)
• EPA Substance Registry System: 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBE&(400608-30-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 400608-30-2(Hazardous Substances Data)

Usage

General Description

1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBENZENE is a chemical compound that consists of a trimethylsilyl group attached to an ethynyl group, and two methoxy groups attached to a benzene ring. 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBE& is commonly used in organic synthesis as a reagent for introducing the trimethylsilyl group into various organic molecules. It is also used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. The trimethylsilyl group provides stability to the compound, allowing for specific reactions or transformations to occur in other parts of the molecule. Overall, 1-TRIMETHYLSILYLETHYNYL-3 5-DIMETHOXYBENZENE is a versatile and important chemical in the field of organic chemistry.

InChI:InChI=1/C13H18O2Si/c1-14-12-8-11(6-7-16(3,4)5)9-13(10-12)15-2/h8-10H,1-5H3

Upstream product

• 25245-27-6 1-iodo-3,5-dimethoxybenzene 
• 1066-54-2 trimethylsilylacetylene 
• 86988-56-9 3,5-Dimethoxy-benzenediazonium; chloride 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 1261302-47-9 (E)-5,5'-(but-1-en-3-yne-1,4-diyl)bis(1,3-dimethoxybenzene) 
• 400608-31-3 1,3-dimethoxy-5-((4-methoxyphenyl)ethynyl)benzene 
• 400608-32-4 5-[(4-hydroxyphenyl)ethynyl]-1,3-benzenediol 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 

Relevant articles and documents

γ-Carboline synthesis enabled by Rh(iii)-catalysed regioselective C-H annulation

A redox-neutral Rh(iii)-catalyzed C-H annulation of indolyl oximes was developed. Relying on the use of various alkynyl silanes as the terminal alkyne surrogates, the reaction exhibited a reverse regioselectivity, thus giving an exclusive and easy way for the synthesis of a wide range of substituent free γ-carbolines at C3 position with high efficiency. Deuterium-labelling experiments and kinetic analysis have preliminarily shed light on the working mode of this catalytic system. This journal is

Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use therefor for effectively treating and/or preventing FGFR-related diseases such as tumors

The present invention relates to an alkynyl-substituted heterocyclic compound serving as an FGFR inhibitor, a preparation method therefor and a medical use therefor. In particular, the present invention relates to a compound represented by the general formula (I) and its pharmaceutically acceptable salt, a pharmaceutical composition including the compound or its pharmaceutically acceptable salt, a method for treating and/or preventing FGFR-related diseases, particularly tumors, by using the compound or its pharmaceutically acceptable salt, and a preparation method of the compound or its pharmaceutically acceptable salt. The present invention also relates to an use of the compound or its pharmaceutically acceptable salt, or an pharmaceutical composition including the compound or its pharmaceutically acceptable salt in the preparation of a drug for treating and/or preventing FGFR-related diseases, particularly tumors, wherein the definition of each substituent in the general formula (I) is the same as that in the specification.

Palladium-catalyzed coupling between aryl halides and trimethylsilylacetylene assisted by dimethylaminotrimethyltin

Palladium-catalyzed coupling between aryl halides, especially less reactive ones or N-heteroaryls, and trimethylsilylacetylene in the presence of dimethylaminotrimethyltin generated the coupled products in high yields. The reaction does not need CuI and base as auxiliary agents.