40061-50-5

Upstream product

• 3360-71-2 diphenyl (phenylamino)(pyridin-3-yl)methylphosphonate 
• 100-68-5 methyl-phenyl-thioether 
• 5398-77-6 para-methanesulfonylbenzaldehyde 
• 40061-49-2 2-(4-methylsulfanyl-phenyl)-1-pyridin-3-yl-ethanone 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 90536-66-6 4-(methylsulfonyl)phenylacetic acid 

Downstream Products

• 481679-80-5 C₃₄H₃₂N₂O₅S₂ 
• 202409-31-2 5-Chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine 

Relevant academic research and scientific papers

PROCESS FOR MAKING 2-ARYL-3-ARYL-5-HALO PYRIDINES USEFUL AS COX-2 INHIBITORS

The invention encompasses a process for making compounds of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases.

Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors

The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.

Substituted pyridines as selective cyclooxygenase-2 inhibitors

The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.

Imidazole derivatives in the treatment of pain

Compounds of the formula SPC1 Wherein R1 represents lower alkyl, cycloalkyl or phenyl which is optionally substituted by halogen, lower alkyl or lower alkoxy, and one of the groups R2 and R3 represents phenyl which is optionally substituted by halogen, lower alkyl, hydroxy, lower alkoxy, lower alkylthio or lower alkylsulphonyl, and the other represents a 6-membered heteroaromatic radical containing 1 or 2 ring nitrogen atoms, their N-oxides and salts, with anti-inflammatory, antinociceptive and antipyretic activity, they are active ingredients of pharmaceutical compositions and can be used for the relief and removal of pain as well as for the treatment of rheumatic, arthritic and other inflammatory complaints; an illustrative example is 2-isopropyl-4(5)-(p-methoxyphenyl)-5(4)-3-pyridyl-imidazole.