40061-64-1

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 104-53-0 3-phenyl-propionaldehyde 
• 16837-38-0 nicotinic anhydride 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 14627-92-0 2-phenyl-1-(pyridin-3-yl)ethanone 
• 67947-67-5 2-bromo-2-phenyl-1-(pyridin-3-yl)-ethanone hydrobromide 

Downstream Products

• 67947-68-6 4-phenyl-5-pyridin-3-yl-1,3-dihydro-imidazole-2-thione 

Relevant academic research and scientific papers

Chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reactions: Importance of the fused ring in triazolium salts

Morpholinone- and piperidinone-derived triazolium salts are shown to catalyze highly chemoselective cross-benzoin reactions between aliphatic and aromatic aldehydes. The reaction scope includes ortho-, meta-, and para-substituted benzaldehyde derivatives with a range of electron-donating and -withdrawing groups as well as branched and unbranched aliphatic aldehydes. Catalytic loadings as low as 5 mol % give excellent yields in these reactions (up to 99%).

Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones

Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones, such as, 4-(4-fluorophenyl)-2-(1,1,2,2-tetrafluoroethylsulfonyl)-5-(2-thienyl)-1H-imidazole, useful for treating arthritis and related diseases.