14257-84-2

Basic information

• Product Name: N-Acetyl-D-phenylglycine
• Synonyms: N-Acetyl-D-phenylglycine;(αR)-α-(Acetylamino)benzeneacetic acid;(2R)-[Acetylamino]-2-phenylacetic acid;Benzeneacetic acid, a-(acetylaMino)-, (R)-;(R)-2-AcetaMido-2-phenylacetic acid
• CAS NO: 14257-84-2
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.20
• Mol File: 14257-84-2.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 439.2 °C at 760 mmHg
• Flash Point: 219.4 °C
• Appearance: /
• Density: 1.233
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Acetyl-D-phenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-D-phenylglycine(14257-84-2)
• EPA Substance Registry System: N-Acetyl-D-phenylglycine(14257-84-2)

Safety Data

• Hazardous Substances Data: 14257-84-2(Hazardous Substances Data)

Usage

General Description

N-Acetyl-D-phenylglycine is a chemical compound that is commonly used as a building block for the synthesis of various pharmaceuticals and organic compounds. It is a derivative of phenylglycine, an amino acid, and contains an acetyl group attached to the amino group. N-Acetyl-D-phenylglycine has a potential role in the development of novel drugs and can be utilized in the production of various chemical products. It has been studied for its pharmacological properties and potential therapeutic applications, making it an important compound in the field of medicinal chemistry and drug development.

Upstream product

• 2835-06-5 phenylglycin 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 100-52-7 benzaldehyde 
• 3076-54-8 phenyllead(IV) triacetate 
• 131934-09-3 ethyl 2-(hydroxyimino)-2-phenylacetate 
• 24461-61-8 phenylglycine methyl ester 
• 171181-53-6 methyl N^α-(diphenylmethylene)-DL-phenylglycinate 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 14304-68-8 N-Acetyl-α-phenylglycine ethyl ester 
• 108-24-7 acetic anhydride 
• 14257-84-2 (S)-N-acetyl-2-phenylglycine 
• 63327-49-1 N-acetyl-α-hydroxyglycine 
• 71-43-2 benzene 

Downstream Products

• 573-34-2 2,4,5-triphenyloxazole 
• 885-75-6 2-amino-1,2-diphenyl-ethanone; hydrochloride 
• 14257-84-2 (S)-N-acetyl-2-phenylglycine 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 130624-93-0 (D)-N^α-acetyl-(3-aminocyclohexyl)glycine 
• 112229-46-6 2-(R)-acetamido-2-(4'-aminocyclohexyl)-acetic acid 
• 112229-46-6 cis-(D)-N^α-acetyl-(4-aminocyclohexyl)glycine 
• 130624-88-3 cis-(DL)-4-hydroxycyclohexylglycine benzyl ester 
• 2935-35-5 (S)-2-phenylglycine 
• 46173-12-0 2-methyl-4-phenyl-Δ²-oxazolin-5-one 
• 86296-96-0 1-Acetyl-5-methyl-2,4-diphenyl-1H-pyrrole-3-carbonitrile 
• 90421-39-9 N-(2-Cyano-2-methyl-4-oxo-1-phenyl-pentyl)-acetamide 
• 126455-20-7 trans-(D)-4-guanidinocyclohexylglycine 
• 126455-20-7 cis-(D)-4-guanidinocyclohexylglycine 

Relevant articles and documents

Reverse Micelles, an Alternative to Aqueous Medium for Microbial Reactions: Yeast-Mediated Resolution of α-Amino Acids in Reverse Micelles

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O-Benzyl derivatives of (S)-(+) and (R)-(-)-2-aminobutan-1-ol as new resolving agents for racemic acids. Practical resolutions of N-acyl derivatives of phenylglycine and 4-hydroxyphenylglycine

Treatment of the readily available (S)-(+) and (R)-(-)-2-aminobutan-1-ol 1 with sodium hydride followed by benzyl chloride, or a substituted benzyl halide, afforded the corresponding O-benzyl bases 2-5 in high yields. These new bases are recommended for the large scale resolution of racemic acids. For instance, they proved efficient for the practical resolution of N-acetylphenylglycine (±)-7, N-acetyl-(4-hyroxylphenyl)glycine (±)-9 and N-chloroacetyl-(4-hydroxyphenyl) glycine (±)-10.

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Regiodivergent Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal Derivatives

Phosphine-catalyzed regiodivergent enantioselective C-2- and C-4-selective γ-additions of oxazolones to 2,3-butadienoates have been developed. The C-4-selective γ-addition of oxazolones occurred in a highly enantioselective manner when 2-aryl-4-alkyloxazol-5-(4H)-ones were employed as pronucleophiles. With the employment of 2-alkyl-4-aryloxazol-5-(4H)-ones as the donor, C-2-selective γ-addition of oxazolones took place in a highly enantioselective manner. The C-4-selective adducts provided rapid access to optically enriched α,α-disubstituted α-amino acid derivatives, and the C-2-selective products led to facile synthesis of chiral N,O-acetals and γ-lactols. Theoretical studies via DFT calculations suggested that the origin of the observed regioselectivity was due to the distortion energy that resulted from the interaction between the nucleophilic oxazolide and the electrophilic phosphonium intermediate.