400649-81-2

Upstream product

• 93966-64-4 3'-benzoyl-5'-O-(4,4'-dimethoxytrityl)thymidine 

Downstream Products

• 400649-82-3 5'-O-(4,4'-dimethoxytrityl)-3'-O-benzoyl-(5S,6R)-5,6-dihydro-5,6-di[(tert-butyl)dimethylsilyloxy]thymidine 
• 400649-83-4 5'-O-(4,4'-dimethoxytrityl)-(5S,6R)-5,6-dihydro-5,6-di[(tert-butyl)dimethylsilyloxy]thymidine 

Relevant academic research and scientific papers

Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycol

Thymine glycol is a major type of base damage, which is formed in DNA by reactive oxygen species. I describe the synthesis of oligonucleotides containing the 5S isomer of thymine glycol, which was not obtained by the oxidation of the oligonucleotides. Bef

Synthesis of thymine glycol containing oligonucleotides from a building block with the oxidized base

One major type of oxidative base damage in DNA is the formation of thymine glycol (shown as part of an oligonucleotide in the picture), which blocks DNA replication. A nucleoside phosphoramidite with this damaged base was synthesized and incorporated into