400715-75-5

Usage

Aromatic compound

It belongs to the class of pyrrole derivatives This means that the compound has a stable, unsaturated ring structure with alternating single and double bonds, contributing to its aromatic nature.

Physical appearance

Pale yellow liquid The chemical appears as a light yellow-colored liquid.

Odor

Pungent The compound has a strong, irritating smell.

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds It is primarily used as a starting material or building block in the production of various drugs and other organic substances.

Application

Reagent in chemical reactions The compound serves as a reactant or catalyst in various chemical processes, such as the formation of heterocyclic compounds.

Environmental and human health hazard

Potential risks 1H-Pyrrole-3-carboxaldehyde,1-ethyl-(9CI) may pose threats to the environment and human health, so proper handling and disposal procedures should be followed to minimize risks.

Upstream product

• 7126-39-8 pyrrole-3-carboxaldehyde 
• 74-88-4 methyl iodide 
• 400715-65-3 3-(3-formyl-1H-pyrrol-1-yl)propanoic acid 
• 400715-68-6 phenyl 3-(3-formyl-1H-pyrrol-1-yl)propaneselenoate 

Relevant academic research and scientific papers

HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS

Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

Novel reversible monoamine oxidase A inhibitors: Highly potent and selective 3-(1 H-pyrrol-3-yl)-2-oxazolidinones

Monoamine oxidases (MAOs) are involved in various psychiatric and neurodegenerative disorders; hence, MAO inhibitors are useful agents in the therapy of Parkinson's disease, Alzheimer's dementia, and depression syndrome. Herein we report a novel series of 3-(1H-pyrrol-3-yl)-2-oxazolidinones 3-7 as reversible, highly potent and selective anti-MAO-A agents. In particular, 4b, 5b, and 4c showed a Ki-MAO-A of 0.6, 0.8, and 1 nM, respectively, 4c being 200000-fold selective for MAO-A with respect to MAO-B.

Bu3SnH-mediated radical cyclisation onto azoles

Alkyl radicals have been cyclised onto pyrroles, imidazoles and pyrazoles, and acyl radicals cyclised onto pyrroles, using Bu3SnH-, (TMS)3SiH- and Bu3GeH-mediated aromatic homolytic substitution for the synthesis of bicyclic N-heterocycles. The reactions yield intermediate π-radicals that lose hydrogen in the?rearomatisation step of the aromatic homolytic substitution. Mechanistic studies of these rearomatisation steps indicate aromatic homolytic substitution in which the initiator or breakdown products from the inhibitor are responsible for the H-abstraction step.

Acyl radical cyclisation onto pyrroles

Synthetically useful [1,2-a]-fused pyrroles, e.g. 2,3-dihydro-1H-pyrrolizidines substituted in the 1- and 7-positions, have been generated by acyl radical cyclisation onto pyrroles using N-(ω-acyl)-radicals generated from acyl-selenide precursors. The protocol does not require high pressures of CO. Mechanistic studies indicate the key role of azo radical initiators as oxidants of the intermediate π-radicals.