400727-04-0

Basic information

• Product Name: 1-(2-pyridinyl)-Cyclopentanecarbonitrile
• Synonyms: 1-(2-pyridinyl)-Cyclopentanecarbonitrile;Cyclopentanecarbonitrile, 1-(2-pyridinyl)-
• CAS NO: 400727-04-0
• Molecular Formula: C11H12N2
• Molecular Weight: 172.22638
• Mol File: 400727-04-0.mol

Chemical Properties

• Boiling Point: 334.051°C at 760 mmHg
• Flash Point: 118.048°C
• Appearance: /
• Density: 1.097g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.553
• PKA: 5.65±0.19(Predicted)
• CAS DataBase Reference: 1-(2-pyridinyl)-Cyclopentanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-pyridinyl)-Cyclopentanecarbonitrile(400727-04-0)
• EPA Substance Registry System: 1-(2-pyridinyl)-Cyclopentanecarbonitrile(400727-04-0)

Safety Data

• Hazardous Substances Data: 400727-04-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(2-pyridinyl)-Cyclopentanecarbonitrile is used as a key intermediate in the synthesis of new compounds for pharmaceutical research. Its unique structure allows for the development of potential therapeutic agents that can target a range of diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-pyridinyl)-Cyclopentanecarbonitrile serves as a versatile building block, enabling the creation of a variety of complex organic molecules with potential applications in various industries.
Used in Agrochemical Production:
1-(2-pyridinyl)-Cyclopentanecarbonitrile is utilized as an intermediate in the production of agrochemicals, contributing to the development of new compounds that can enhance crop protection and yield.
Used in Specialty Chemicals Manufacturing:
1-(2-pyridinyl)-Cyclopentanecarbonitrile also finds application in the manufacturing of specialty chemicals, where its unique properties are leveraged to create high-value products for specific industrial applications.

InChI:InChI=1/C11H12N2/c12-9-11(6-2-3-7-11)10-5-1-4-8-13-10/h1,4-5,8H,2-3,6-7H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 2739-97-1 pyridine-2-acetonitrile 

Downstream Products

• 1616925-58-6 5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester 
• 1616925-59-7 5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid 
• 1616925-60-0 5-benzyloxy-6-hydroxy-2-(1-pyridin-2-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide 

Relevant articles and documents

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Lithium naphthalenide-induced reductive alkylation and addition of aryl-and heteroaryl-substituted dialkylacetonitriles

Lithium naphthalenide (LN)-induced reductive alkylation/addition reactions of aryl-, pyridyl-, and 2-thienyl-substituted dialkylacetonitriles have been investigated. Upon treatment with LN in THF at -40°C, both aryl and pyridyl precursors could undergo the reductive decyanation smoothly, and the in situ generated carbanions could be readily trapped by alkyl halides, ketones, aldehydes, or even oxygen to afford a wide range of functionalized aromatic derivatives bearing a newly established quaternary carbon. To effect the desired reductive alkylation of 2-thienyldialkylacetonitriles, a much lower temperature such as -100°C was required. Also with these substrates, an interesting ring-opening/S-alkylation process was observed when the reductive alkylation were performed at -78°C to give 1-alkylsulfanyl-1,3,4-trienes. A mechanistic discussion is given for this observation.