400727-63-1

Usage

Uses

Used in Organic Synthesis:
N-Boc-5-aminoisoindoline is used as a key intermediate for the synthesis of various complex organic molecules. Its Boc protecting group allows for selective reactions to occur at other sites on the molecule, facilitating the construction of intricate molecular architectures.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-Boc-5-aminoisoindoline is utilized as a building block for the development of pharmaceuticals and other bioactive compounds. Its structural features contribute to the design of novel molecules with potential therapeutic applications.
Used in Drug Development:
N-Boc-5-aminoisoindoline plays a significant role in drug development, where it serves as a precursor to compounds with potential medicinal properties. Its versatility in organic synthesis allows for the exploration of new chemical space, leading to the discovery of innovative drug candidates.

InChI:InChI=1/C13H16N2O4/c1-13(2,3)19-12(16)14-7-9-4-5-11(15(17)18)6-10(9)8-14/h4-6H,7-8H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 46053-72-9 5-nitroisoindoline 
• 496-12-8 isoindoline 
• 1059172-96-1 2,2,2-trifluoro-1-(5-nitroisoindolin-2-yl)ethan-1-one 
• 832-51-9 1-(1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroethanone 

Downstream Products

• 1264924-35-7 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol 
• 1264924-32-4 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate 
• 807627-86-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine 
• 807627-84-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine methyl ester 
• 945488-76-6 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopentyloxyphenyl)-β-alanine 
• 945488-74-4 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-butoxyphenyl)-β-alanine 
• 945488-75-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isobutyloxyphenyl)-β-alanine 
• 945488-72-2 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-propoxyphenyl)-β-alanine 
• 945488-77-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine 
• 945488-71-1 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-ethoxyphenyl)-β-alanine 
• 945488-73-3 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopropoxyphenyl)-β-alanine 
• 945488-70-0 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-methoxyphenyl)-β-alanine 
• 264916-06-5 tert‐butyl 5‐amino‐2,3‐dihydro‐1H‐isoindole‐2‐carboxylate 

Relevant academic research and scientific papers

THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF

The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

HETEROARYL COMPOUNDS AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of one or more protein kinases. Such compounds have general formula I or a pharmaceutically acceptable salt thereof, wherein Ring A, Ring B, W, Ry, R3 and R4 are as defined herein.

PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS

The present invention relates to novel heterocyclic compounds of Formulae (I): (Chemical formula should be inserted here as it appears on abstract in paper form) Formula (I) as disclosed herein, or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.

4-(Isoindolin-5-yl)amino-4-oxobutyryl-β-alkoxyphenyl-β-alanines, new RGDF mimetics. Synthesis, affinity to fibrinogen receptors, antiaggregatory properties, and their correlation with the hydrophobicity

A new series of RGDF mimetics, derivatives of 4-(isoindolin-5-yl)amino-4- oxobutanoic acid, was synthesized. The compounds obtained inhibit efficiently the thrombocytes aggregation in experiments in vitro; their biological targets are fibrinogen receptors

Novel fibrinogen receptor antagonists. RGDF mimetics, derivatives of 4-(isoindoline-5-yl)amino-4-oxobutyric acid

The novel RGDF mimetics 9a and 9b were synthesized with the use of 4-(isoindoline-5-yl)amino-4-oxobutyric acid as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to bloc