807627-86-7Relevant academic research and scientific papers
4-(Isoindolin-5-yl)amino-4-oxobutyryl-β-alkoxyphenyl-β-alanines, new RGDF mimetics. Synthesis, affinity to fibrinogen receptors, antiaggregatory properties, and their correlation with the hydrophobicity
Andronati,Krys'ko,Chugunov,Kabanova,Artemenko
, p. 1174 - 1182 (2007/10/03)
A new series of RGDF mimetics, derivatives of 4-(isoindolin-5-yl)amino-4- oxobutanoic acid, was synthesized. The compounds obtained inhibit efficiently the thrombocytes aggregation in experiments in vitro; their biological targets are fibrinogen receptors
Novel fibrinogen receptor antagonists. RGDF mimetics, derivatives of 4-(isoindoline-5-yl)amino-4-oxobutyric acid
Krysko, Andrei A.,Chugunov, Boris M.,Malovichko, Olga L.,Andronati, Sergei A.,Kabanova, Tatyana A.,Karaseva, Tamara L.,Kiriyak, Anna V.
, p. 5533 - 5535 (2007/10/03)
The novel RGDF mimetics 9a and 9b were synthesized with the use of 4-(isoindoline-5-yl)amino-4-oxobutyric acid as a surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to bloc
