400744-34-5 Usage
Uses
Used in Textile Industry:
4'-Benzyloxy-biphenyl-3-ylamine is used as a precursor in the synthesis of azo dyes for the textile industry, where it contributes to the production of vibrant and long-lasting colors in fabrics. The dyes derived from benzidine are valued for their ability to produce a wide range of hues and their resistance to fading.
Used in Paper Industry:
In the paper industry, 4'-Benzyloxy-biphenyl-3-ylamine is used as a component in dye formulations to impart color to paper products. The azo dyes produced using benzidine enhance the visual appeal and aesthetic quality of paper, making it suitable for various applications such as printing, packaging, and stationery.
Used in Plastics Industry:
4'-Benzyloxy-biphenyl-3-ylamine is utilized in the plastics industry as a key ingredient in the creation of colored plastics. The azo dyes derived from benzidine provide a broad spectrum of colors for plastic materials, which can be used in the manufacturing of various consumer goods, toys, and decorative items.
However, it is crucial to note that benzidine has been identified as a human carcinogen, posing an increased risk of bladder cancer and other health issues. Due to its hazardous nature, the use of benzidine has been restricted or banned in many countries. As a result, the dye industry has been actively seeking and adopting safer alternative chemicals to replace benzidine in dye production processes.
Check Digit Verification of cas no
The CAS Registry Mumber 400744-34-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,7,4 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 400744-34:
(8*4)+(7*0)+(6*0)+(5*7)+(4*4)+(3*4)+(2*3)+(1*4)=105
105 % 10 = 5
So 400744-34-5 is a valid CAS Registry Number.
400744-34-5Relevant academic research and scientific papers
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold
Adinolfi, Salvatore,Bagnati, Renzo,Boschi, Donatella,Denasio, Enrica,Kovachka, Sandra,Lolli, Marco Lucio,Oliaro-Bosso, Simonetta,Pippione, Agnese Chiara,Pors, Klaus,Rolando, Barbara,Sainas, Stefano,Spyrakis, Francesca,Zonari, Daniele,Kilic-Kurt, Zühal
, (2022/04/21)
The aldo-keto reductase 1C3 (AKR1C3) enzyme is considered an attractive target in Castration Resistant Prostate Cancer (CRPC) because of its role in the biosynthesis of androgens. Flufenamic acid, a non-selective AKR1C3 inhibitor, has previously been subjected to bioisosteric modulation to give rise to a series of compounds with the hydroxytriazole core. In this work, the hit compound of the previous series has been modulated further, and new, more potent, and selective derivatives have been obtained. The poor solubility of the most active compound (cpd 5) has been improved by substituting the triazole core with an isoxazole heteronucleous, with similar enzymatic activity being retained. Potent AKR1C3 inhibition is translated into antiproliferative effects against the 22RV1 CRPC cellular model, and the in-silico design, synthesis and biological activity of new compounds are described herein. Compounds have also been assayed in combination with two approved antitumor drugs, abiraterone and enzalutamide.
