400746-87-4

Upstream product

• 1260244-94-7 2-[2-(1,3-dioxolan-2-yl)phenyl]nitrobenzene 
• 577-19-5 2-nitrophenyl bromide 
• 68182-83-2 2'-nitro[1,1'-biphenyl]-2-carbaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1260245-09-7 N'-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-N-tert-butoxycarbonyl-(S)-phenylalanine amide 
• 1260245-07-5 N'-[2'-(1,3-dioxolan-2-yl)[1,1'-biphenyl]-2-yl]-N-tert-butoxycarbonyl-(R)-phenylalanine amide 

Relevant academic research and scientific papers

Asymmetric synthesis of novel biaryl analogues with a fused chiral bicyclic bridge using -amino acids as chiral sources

A series of biaryl anologues with a fused bicyclic bridge were synthesised in a diastereoselectivity of up to 14:86 via an intramolecular cyclisation of an in situ generated N-acyliminium ion. The absolute configuration of products 9b-d and 10b-d was clea

Asymmetric synthesis and structural elucidation of C2- Symmetrical optically active macrocycles consisting of two biaryl and two -amino acid moieties

A series of chiral C2-symmetrical macrocycles containing two -amino acids and two biaryl subunits have been designed and synthesized in moderate yields (36-53%). The absolute configurations of biaryl motifs in these chiral macrocycles were established by X-ray crystal structure analysis and CD measurements. Georg Thieme Verlag Stuttgart New York.