40076-74-2Relevant academic research and scientific papers
Copper-Catalyzed Aerobic Oxidative C-C Bond Cleavage of Unstrained Ketones with Air and Amines
Zhou, Wang,Fan, Wenyou,Jiang, Qijian,Liang, Yu-Feng,Jiao, Ning
, p. 2542 - 2545 (2015)
A unique copper-catalyzed aerobic oxidative C-C bond cleavage of simple unstrained ketones with air and amines has been developed. In this chemistry, amides and oxo amides are easily synthesized through the selective C-C bond cleavage of simple ketones or unstrained cycloketones. The broad substrate scopes and use of an inexpensive copper catalyst and green molecular oxygen as an oxidant as well as an O-source make this protocol very attractive for potential synthetic applications. The control experiments reveal that the present copper-catalyzed oxidative C-C bond cleavage of simple ketones proceeds in a novel catalytic pathway rather than through the cleavage of a dioxetane intermediate. (Chemical Equation Presented).
Synergistic palladium/enamine catalysis for asymmetric hydrocarbon functionalization of unactivated alkenes with ketones
Wei, Chiyu,Ye, Xiaohan,Xing, Qingyu,Hu, Yong,Xie, Yan,Shi, Xiaodong
, p. 6607 - 6611 (2019)
Synergistic palladium and enamine catalysis was explored to promote ketone addition to unactivated olefins. A secondary amine-based organocatalyst was identified as the optimal co-catalyst for the directed Pd-catalyzed alkene activation. Furthermore, asymmetric hydrocarbon functionalization of unactivated alkenes was also achieved with good to excellent yield (up to 96% yields) and stereoselectivity (up to 96% ee). This strategy presented an efficient approach to prepare α-branched ketone derivatives under mild conditions.
6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: Novel HIV protease inhibitors
Hamilton, Harriet W.,Tait, Bradley D.,Gajda, Christopher,Hagen, Susan E.,Ferguson, Donna,Lunney, Elizabeth A.,Pavlovsky, Alexander,Tummino, Peter J.
, p. 719 - 724 (2007/10/03)
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones as HIV protease inhibitors. The current work examines the analogues 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the use of 1
