400764-08-1

Upstream product

• 647014-92-4 9-(tert-butyl-dimethyl-silanyloxy)-4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-3-methoxy-non-7-ynyl]-2-methoxy-7-[3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-2,8,10-trimethyl-1,3,6-trioxa-spiro[4.5]decane 
• 400763-80-6 5-(tert-butyl-dimethyl-silanyloxy)-1-{4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-6-[3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-3,5-dimethyl-tetrahydro-pyran-2-yl}-2-(3,4-dimethoxy-benzyloxy)-9-iodo-4-methoxy-dec-8-en-1-one 
• 647014-83-3 (1S,2S,4S,5S)-1-{2-[(1R,2S,3S,4R,6R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-6-(4-methoxy-benzyloxy)-1,3-dimethyl-heptyl]-[1,3]dithian-2-yl}-5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-4-methoxy-dec-8-yn-1-ol 
• 647014-82-2 (1R,2S,4S,5S)-1-{2-[(1R,2S,3S,4R,6R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-6-(4-methoxy-benzyloxy)-1,3-dimethyl-heptyl]-[1,3]dithian-2-yl}-5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-4-methoxy-dec-8-yn-1-ol 
• 400763-78-2 5-(tert-butyl-dimethyl-silanyloxy)-1-{4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-6-[3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-3,5-dimethyl-tetrahydro-pyran-2-yl}-2-(3,4-dimethoxy-benzyloxy)-9-iodo-4-methoxy-dec-8-en-1-ol 
• 647014-93-5 9-(tert-butyl-dimethyl-silanyloxy)-4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-3-methoxy-non-7-ynyl]-2-methoxy-7-[3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-2,8,10-trimethyl-1,3,6-trioxa-spiro[4.5]decane 
• 647014-88-8 9-(tert-butyl-dimethyl-silanyloxy)-4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-3-methoxy-non-7-ynyl]-7-[3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-8,10-dimethyl-1,3,6-trioxa-spiro[4.5]decan-2-one 
• 400763-73-7 9-(tert-butyl-dimethyl-silanyloxy)-4-[4-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-3-methoxy-non-7-ynyl]-7-[3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-8,10-dimethyl-1,3,6-trioxa-spiro[4.5]decan-2-one 
• 647014-87-7 (2R,3R,4S,5S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-[(1S,2S,4S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-1-hydroxy-4-methoxy-dec-8-ynyl]-6-[(R)-3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-3,5-dimethyl-tetrahydro-pyran-2-ol 
• 400736-37-0 2-[(1R,2S,3S,4R,6R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-6-(4-methoxy-benzyloxy)-1,3-dimethyl-heptyl]-[1,3]dithiane 
• 400736-32-5 (2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-4-methoxy-dec-8-ynal 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 647014-86-6 (2R,3R,4S,5S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-[(1R,2S,4S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-(3,4-dimethoxy-benzyloxy)-1-hydroxy-4-methoxy-dec-8-ynyl]-6-[(R)-3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-3,5-dimethyl-tetrahydro-pyran-2-ol 

Relevant academic research and scientific papers

Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation

The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a seco

Total synthesis of apoptolidin: Part 2. Coupling of key building blocks and completion of the synthesis

No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique biological activity, make the natural occurring apoptolidin (1) a challenging synthetic target. The retrosynthetic analysis reve