400764-08-1Relevant articles and documents
Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation
Nicolaou,Li, Yiwei,Sugita, Kazuyuki,Monenschein, Holger,Guntupalli, Prasuna,Mitchell, Helen J.,Fylaktakidou, Konstantina C.,Vourloumis, Dionisios,Giannakakou, Paraskevi,O'Brate, Aurora
, p. 15443 - 15454 (2007/10/03)
The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a seco