647014-86-6Relevant articles and documents
Total synthesis of apoptolidin: Part 2. Coupling of key building blocks and completion of the synthesis
Nicolaou,Li, Yiwei,Fylaktakidou, Konstantina C.,Mitchell, Helen J.,Sugita, Kazuyuki
, p. 3854 - 3857 (2001)
No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique biological activity, make the natural occurring apoptolidin (1) a challenging synthetic target. The retrosynthetic analysis reve