400775-35-1 Usage
Description
Bis-Propargyl-PEG7 is a homobifunctional reagent characterized by its two propargyl groups, which enable the formation of triazole linkages with azide-bearing compounds or biomolecules through a copper-catalyzed Click Chemistry process. The presence of hydrophilic PEG (polyethylene glycol) units significantly enhances the solubility of the molecule in aqueous environments, making it a versatile tool in various applications.
Uses
Used in Bioconjugation:
Bis-Propargyl-PEG7 is used as a linker for bioconjugation, facilitating the covalent attachment of biomolecules, such as proteins, nucleic acids, or other ligands, to form stable triazole linkages. The hydrophilic PEG units improve the solubility and stability of the resulting conjugates in aqueous solutions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bis-Propargyl-PEG7 is used as a component in drug delivery systems to enhance the solubility, bioavailability, and circulation time of therapeutic agents. The PEGylation of drugs can help reduce immunogenicity and improve the pharmacokinetic properties of the drug molecules.
Used in Material Science:
Bis-Propargyl-PEG7 is utilized as a building block in the development of novel materials with tailored properties, such as hydrogels, for various applications, including tissue engineering and controlled release systems. The triazole linkages formed through Click Chemistry provide robust and stable connections between the PEG units, allowing for the creation of well-defined structures with specific mechanical and biological properties.
Used in Chemical Synthesis:
In organic synthesis, Bis-Propargyl-PEG7 serves as a versatile reagent for the synthesis of complex molecular architectures. The propargyl groups can be used to introduce azide-bearing moieties into a molecule, which can then be further modified through Click Chemistry to create a diverse range of products with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.
Used in Diagnostics:
Bis-Propargyl-PEG7 is employed as a component in the development of diagnostic tools, such as imaging agents and sensors, that rely on the specific recognition and binding of target molecules. The PEGylation of these diagnostic agents can improve their solubility, stability, and biocompatibility, leading to enhanced performance in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 400775-35-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,0,7,7 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 400775-35:
(8*4)+(7*0)+(6*0)+(5*7)+(4*7)+(3*5)+(2*3)+(1*5)=121
121 % 10 = 1
So 400775-35-1 is a valid CAS Registry Number.
400775-35-1Relevant articles and documents
Synthesis, DNA cleavage, and cytotoxicity of a series of bis(propargylic) sulfone crown ethers
McPhee, Mark M.,Kerwin, Sean M.
, p. 2809 - 2818 (2001)
Compound that couple molecular recognition of specific alkali metal ions with DNA damage may display selective cleavage of DNA under condition of elevated alkali metal ion level reported to exist in certain cancer cell . We have prepared a homologous serie of compound in which a DNA reactive moiety, a bis (propargylic) sulfone, is incorporated into an alkali metal ion binding crown ether ring. Using the alkali metal ion pricrate extraction assay, the ability of these crown ether to bind Li+, Na+, and K+, ions was determined. For the series of crown ethers , the association constant for Li+ ions are generally low (4M-1). Only two of the bis(propargylic) sulfone crown ethers associate with Na+ or K+ ions (Ka 4 8 x 104M-1), with little discrimination between Na+ or K+ ions. The ability of these compounds to cleave supercoiled DNA at pH 7.4 in the presence of Li+, Na+ , and K+ ions was determined. The two crown ethers that bind Na+ and K+ display a modest increase in DNA cleavage efficiency in the presence of Na+ or K+ ions as compared to Li+ ions. These two bis (propargylic) sulfone crown ethers are also more cytotoxic against a panel of human cancer cell line when compared to a non-crown ether macrocyclic bis(propargylic) sulfone. Copyright
