400778-04-3Relevant academic research and scientific papers
Total synthesis of anti-HIV agent chloropeptin I
Deng, Hongbo,Jung, Jae-Kyung,Liu, Tao,Kuntz, Kevin W.,Snapper, Marc L.,Hoveyda, Amir H.
, p. 9032 - 9034 (2007/10/03)
A convergent diastereo- and enantioselective total synthesis of anti-HIV agent chloropeptin I is reported. Important features of the total synthesis include: (1) the use of Ti-catalyzed cyanide addition to imines to prepare a requisite amino acid moiety,
STRUCTURE OF COMPLESTATIN, A VERY STRONG INHIBITOR OF PROTEASE ACTIVITY OF COMPLEMENT IN THE HUMAN COMPLEMENT SYSTEM
Seto, Haruo,Fujioka, Tomoyuki,Furihata, Kazuo,Kaneko, Isao,Takahashi, Shuji
, p. 4987 - 4990 (2007/10/02)
The structure of complestatin, which strongly inhibits the protease activity of complements in the human complement system, has been determined as shown in Fig.2 mainly based on HMBC.Its structure is closely related to glycopeptide antibiotics.
