4008-46-2

Basic information

• Product Name: Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate
• Synonyms: 4-Hydroxy-8-Methoxy-quinoline-2-carboxylic acid Methyl ester;Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate
• CAS NO: 4008-46-2
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22
• Mol File: 4008-46-2.mol

Chemical Properties

• Melting Point: 159-160 °C
• Boiling Point: 445.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.316
• PKA: 6.85±0.40(Predicted)
• CAS DataBase Reference: Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate(4008-46-2)
• EPA Substance Registry System: Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate(4008-46-2)

Safety Data

• Hazardous Substances Data: 4008-46-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate is used as an intermediate in the synthesis of various pharmaceuticals for its potential antioxidant, antimicrobial, and antiviral properties. These properties contribute to the development of drugs that can combat a range of health issues, including infections and oxidative stress-related conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate serves as an intermediate in the production of agrochemicals. Its antimicrobial properties are particularly beneficial in creating compounds that protect crops from diseases and pests, thereby enhancing agricultural productivity and crop quality.
Used as an Antioxidant:
Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate is utilized as an antioxidant in various applications, including in the food industry to extend the shelf life of products and in the cosmetic industry to protect against environmental damage and premature aging.
Used as an Antimicrobial Agent:
Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate is employed as an antimicrobial agent in different settings, such as in medical applications to prevent infections and in industrial processes to control microbial growth that could affect product quality or safety.
Used as an Antiviral Agent:
Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate is used in the development of antiviral agents, potentially offering treatments for a variety of viral infections by inhibiting viral replication or entry into host cells.
It is important to handle and store Methyl 4-hydroxy-8-methoxyquinoline-2-carboxylate in a dry, cool, and well-ventilated area to maintain its stability and effectiveness.

Upstream product

• 25007-54-9 Dimethyl 2-oxosuccinate 
• 90-04-0 2-methoxy-phenylamine 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 7101-82-8 dimethyl 2-((2-methoxyphenyl)amino)but-2-enedioate 

Downstream Products

• 21638-90-4 methyl 8-hydroxyquinoline-2-carboxylate 
• 1571-30-8 8-hydroxy-quinoline-2-carboxylic acid 
• 59-00-7 xanthurenic acid 

Relevant articles and documents

TiO2 modified with a Ru(ii)-N′NN′ 8-hydroxyquinolyl complex for efficient gaseous photoreduction of CO2

A new rigid neutral Ru(ii) pincer complex [Ru(N′NN′)(ONO)] was synthesized from cationic [Ru(N′NN′)(MeCN)2Cl]Cl (N′NN′, 2,6-bis(N-benzyl-benzimidazol-2-yl)pyridine) and 4,8-dihydroxyquiniline-2-carboxylic acid (ONO). The X-ray diffraction analysis indicates that the Ru(ii) center adopts a slightly distorted octahedral geometry, in which the two benzyl moieties of the N′NN′ ligand are located on the same side of the coordination plane, defined by three N atoms of N′NN′ and the Ru(ii) center, and the dihedral angles of the benzyl group and the Ru(ii)-N′NN′ plane are 89.1° and 74.9°, respectively. Upon loading onto TiO2 nanoparticles (P25), this Ru(ii) complex exhibits an efficient CO2 photoreduction ability with CO/CH4 production activities of 26.6/17.2 μmol g-1 h-1 in a gaseous photocatalytic system containing CO2 and H2O vapor, which is much better than that of the pristine TiO2 nanoparticles. This result gives a good example of TiO2 nanoparticles loaded with the Ru(ii) pincer complex acting as a heterogeneous photocatalytic CO2 reduction system, which could facilitate the development of a more feasible artificial photosynthesis system.

SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS

The invention relates to a compound of a formula (I): , or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.

2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS

Compounds of formula (I), where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Platelet adenosine diphosphate receptor antagonists

Compounds of the following formula (I): where a, b, R1, R2, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, met