400819-99-0Relevant academic research and scientific papers
Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's dis
Prasad,Zheng, Ming,Vig, Shikha,Bergstrom, Carl,Smith, David W.,Gao, Qi,Yeola, Suresh,Polson, Craig T.,Corsa, Jason A.,Guss, Valerie L.,Loo, Alice,Wang, Jian,Sleczka, Bogdan G.,Dangler, Charles,Robertson, Barbara J.,Hendrick, Joseph P.,Roberts, Susan B.,Barten, Donna M.
, p. 4006 - 4011 (2008/02/09)
We report on the design of benzodiazepinones as peptidomimetics at the carboxy terminus of hydroxyamides. Structure-activity relationships of diazepinones were investigated and orally active γ-secretase inhibitors were synthesized. Active metabolites cont
Tetrazolylpropionamides as inhibitors of Abeta protein production
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Page/Page column 26, (2010/02/06)
This invention relates to novel tetrazolylpropionamides in which the amide group comprises an aminoazepinone, and related structures, of Formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, their pharmaceutical compositions and metho
Benzodiazepinone beta -amyloid inhibitors: arylacetamidoalanyl derivatives
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, (2008/06/13)
There is provided a series of arylacetamidoalanyl derivatives of benzodiazepinones of Formula I wherein R1 through R7 and n are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extract cellular deposition of amyloid.
