1723-55-3

Usage

Uses

Used in Fragrance Industry:
Benzeneacetic acid, 2-formylis used as a key ingredient in the production of fragrances for its sweet, honey-like odor, enhancing the overall scent profile of various perfumes and scented products.
Used in Flavor Industry:
In the flavor industry, Benzeneacetic acid, 2-formylis utilized for its distinctive sweet taste, contributing to the flavor profiles of food and beverage products.
Used in Pharmaceutical Industry:
Benzeneacetic acid, 2-formylis used as a precursor in the synthesis of various pharmaceuticals, including amphetamines and other medicinal compounds, due to its versatile chemical structure and reactivity.
Used in Chemical Synthesis:
As an important intermediate in organic chemistry, Benzeneacetic acid, 2-formylis used in the manufacturing of a wide range of products, serving as a building block for the creation of new chemical entities and compounds.

Upstream product

• 615-13-4 2-indanone 
• 95-13-6 1-indene 
• 63969-84-6 ethyl 2-formyl-phenyl-acetate 
• 95683-63-9 2-<(Trimethylsilyl)oxy>indene 
• 78176-76-8 Indan-2-one enol ethyl ether 
• 55630-93-8 3-oxo-isochroman-1-carboxylic acid 

Downstream Products

• 63969-83-5 2-formylphenylacetic acid methyl ester 
• 400819-99-0 4,5-dihydro-3-methyl-3H-2,3-benzodiazepin-4-one 
• 116206-45-2 Methyl 2-<3-oxo-4-(3-chlorophenoxy)-1E-butenyl>phenylacetate 
• 116206-48-5 Methyl 2-<3-hydroxy-4-(3-chlorophenyl)-1E-butenyl>phenylacetate 
• 116206-44-1 Methyl 2-<3-oxo-5-(2-furyl)-1E-pentenyl>phenylacetate 
• 116206-47-4 Methyl 2-<3-hydroxy-5-(2-furyl)-1E-pentenyl>phenylacetate 
• 116206-43-0 2-(3-oxo-1E-octenyl)phenylacetic acid methyl ester 
• 116206-46-3 2-(3-hydroxy-1E-octenyl)phenylacetic acid methyl ester 

Relevant academic research and scientific papers

2-Benzopyran-3-ones as Synthetic Building Blocks; Regioselective Diels-Alder Additions with Simple Olefins leading to Aromatic Steroids

2-Benzopyran-3-one 1a undergoes strongly regioselective Diels-Alder additions to buta-1,3-diene, 2-methylpropene, but-1-ene and the olefin 9.The main adducts 17a and 17b from 1a and 1b respectively and the olefin 9(=16) are derived by endo- and exo-addition to the re-face of 9(=16).These adducts are converted into the 8α,9α-steroids 22a and 22b by a four-step sequence including Dieckmann cyclisation of 21a and 21b as the key step.The derived 8α,9α-steroids 24a and 24b can be epimerised at C-8 via the enones 26a and 26b and lithium-ammonia reduction.Other aromatic steroids obtained by this general route are the equilenin derivative 28 and the dihydronaphthalene 29.

PROSTANOIDS. SYNTHESIS OF &α-PENTANORBENZO ANALOGS OF PROSTAGLANDINS

The α-pentanorbenzo analogs of prostaglandins were synthesized from o-formylphenylacetic acid, which was obtained by the ozonization of indene under specific conditions.

Regioselective Diels-Alder Addition to 2-Benzopyran-3-ones; a Route to Aromatic Steroids

2-Benzopyran-3-one (1; X=H) undergoes strongly regioselective Diels-Alder additions to buta-1,3-diene, isobutene, but-1-ene, and the olefin (6); the adducts derived from (6) and either (1; X = H) or (1; X = OMe) are readily transformed into the aromatic steroids: (9), (10), (17), (18), 9-epi-(10), 9-epi-(18), the naphthalene (14), and the dihydronaphthalene (15).

CYCLOADDITIONS OF BENZOPYRONES: RAPID ACCESS TO BICYCLIC AB-RING ANALOGUES OF ANTHRACYCLINES

Cycloaddition of benzopyrone 10b with 1,1-disubstituted alkenes 12, 14, and 16 produces fair yields of the lactones 13, 15, and 17 AB-ring analogues of the anthracyclines.