400827-68-1

Basic information

• Product Name: benzhydryl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[4-(4-pyridyl)thiazol-2-yl]sulfanyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS NO: 400827-68-1
• Molecular Formula: C₃₆H₂₈N₄O₄S₃
• Molecular Weight: 676.83
• Mol File: 400827-68-1.mol
• Article Data: 3

Chemical Properties

• Density: 1.47g/cm³
• Refractive Index: 1.746
• CAS DataBase Reference: benzhydryl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[4-(4-pyridyl)thiazol-2-yl]sulfanyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzhydryl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[4-(4-pyridyl)thiazol-2-yl]sulfanyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate(400827-68-1)
• EPA Substance Registry System: benzhydryl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-[4-(4-pyridyl)thiazol-2-yl]sulfanyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate(400827-68-1)

Safety Data

• Hazardous Substances Data: 400827-68-1(Hazardous Substances Data)

Upstream product

• 92096-37-2 benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[(methylsulfonyl)oxy]-3-cephem-4-carboxylate 
• 77168-63-9 [4-(4-pyridyl)-1,3-thiazol-2-yl]thiol 
• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 189345-52-6 7β-amino-3-[4-(1-methyl-4-pyridinio)-1,3-thiazol-2-yl]thio-3-cephem-4-carboxylate 
• 400827-64-7 4-[2-[[(6R,7R)-7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]-thio]-4-thiazolyl]-1-methylpyridiniumchloride hydrochloride 
• 229016-73-3 ceftaroline 

Relevant articles and documents

MANUFACTURING METHOD OF INTERMEDIATE FOR PREPARATION OF CEPHALOSPORIN DERIVATIVE AND CEFTAROLINE FOSAMIL METAL SALT MANUFACTURED THEREBY

The present invention relates to a method for preparing an intermediate for the preparation of a cephalosporin compound, and a ceftaroline fosamil metal salt obtained therefrom. According to the method for preparing an intermediate for the preparation of

TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties

Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2′ (IC50; 0.90 μg/mL) and shows potent in v