40099-50-1

Upstream product

• 63-91-2 L-phenylalanine 
• 18701-36-5 2-([1,1-biphenyl]-4-yl)propan-2-yl phenyl carbonate 
• 31055-21-7 2-(p-Biphenylyl)-iso-propyloxycarbonylfluorid 
• 34352-74-4 2-biphenyl-4-yl-propan-2-ol 
• 99503-06-7 Carbonic acid 1-biphenyl-4-yl-1-methyl-ethyl ester 3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester 

Downstream Products

• 63-91-2 L-phenylalanine 
• 65895-53-6 Bpoc-Phe-ONSu 
• 108826-87-5 Bpoc-Phe-D-Trp-Lys(Boc)-Thr(t-Bu)-OH 
• 87325-55-1 Bpoc-Phe-D-A₂hy(Boc)-OH 
• 65042-62-8 Bpoc-Phe-Asn-Thr(Bu^t)-Gln-Ala-OPh 
• 108826-86-4 Bpoc-Phe-D-Trp-Lys(Boc)-Thr(t-Bu)-OTmse 

Relevant academic research and scientific papers

The synthesis of phosphopeptides via the Bpoc-based approach

The 2-(p-biphenylyl)-2-propyloxycarbonyl (Bpoc) group was examined as an Nα-protecting group in the stepwise assembly of the MAP Kinase ERK2 [178-188; Thr(P)183, Tyr(P)185] peptide. The mild acid deprotection of the Bpoc group permitted (i) incorporation of a fully protected phosphothreonyl derivative and (ii) a TFA-based final cleavage step. The first five C-terminal residues (184-188) were incorporated in the Fmoc mode of peptide synthesis, with all subsequent amino acids coupled as their Bpoc-Xxx-OH derivatives. The target product was obtained in high purity and yield, indicating that a Bpoc-based approach to phosphopeptide synthesis was compatible with both the acid-labile side chain protecting groups employed and Hmp-Wang resin. This journal is The Royal Society of Chemistry.

5-Norbornene-2,3-dicarboximido Carbonochloridate. A New Stable Reagent for the Introduction of Amino-Protecting Groups

The synthesis of activated carbonates, based on a new carbonochloridate derived from N-hydroxy-5-norbornene-2,3-dicarboximide, is reported.These activated carbonic esters are excellent reagents for the introduction of all currently used urethane protecting groups.