401-77-4 Usage
General Description
3-Fluorobenzotrichloride is a synthetic, organically based chemical compound distinguished by the inclusion of three fluorine atoms and a benzene ring in its molecular structure. 3-FLUOROBENZOTRICHLORIDE exhibits properties common to other fluorinated chemicals, such as unique reactivity and stability. It can participate in a broad range of chemical reactions, serving as a key ingredient in the synthesis of other organic molecules. Like many similar compounds, proper handling and disposal of 3-fluorobenzotrichloride is crucial to prevent environmental contamination and potential health hazards. It's mostly used in industrial applications, primarily in the production of pharmaceuticals and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 401-77-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 401-77:
(5*4)+(4*0)+(3*1)+(2*7)+(1*7)=44
44 % 10 = 4
So 401-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H4Cl3F/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4H
401-77-4Relevant articles and documents
Iron-Catalyzed Halogen Exchange of Trifluoromethyl Arenes**
Dorian, Andreas,Landgreen, Emily J.,Petras, Hayley R.,Shepherd, James J.,Williams, Florence J.
supporting information, p. 10839 - 10843 (2021/06/21)
The facile production of ArCF2X and ArCX3 from ArCF3 using catalytic iron(III)halides is reported, which constitutes the first iron-catalyzed halogen exchange for non-aromatic C?F bonds. Theoretical calculations suggest direct activation of C?F bonds by iron coordination. ArCX3 and ArCF2X products of the reaction are synthetically valuable due to their diversification potential. In particular, chloro- and bromodifluoromethyl arenes (ArCF2Cl, ArCF2Br respectively) provide access to a myriad of difluoromethyl arene derivatives (ArCF2R). To optimize for mono-halogen exchange, a statistical method called Design of Experiments was used. Optimized parameters were successfully applied to electron rich and electron deficient aromatic substrates, and to the late stage diversification of flufenoxuron, a commercial insecticide. These methods are highly practical, being run at convenient temperatures and using inexpensive common reagents.
