402-64-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluorobenzal chloride is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluorobenzal chloride is utilized as a precursor in the production of agrochemicals, enhancing crop protection and yield.
Used in Dye and Pigment Synthesis:
3-Fluorobenzal chloride is employed as a building block in the synthesis of dyes and pigments, offering a wide range of color options for various applications.
Used in Polymer Industry:
3-FLUOROBENZAL CHLORIDE is used as a monomer or a reactant in the production of polymers, contributing to the development of new materials with specific properties.
Safety Precautions:
Due to its highly corrosive and toxic nature, 3-Fluorobenzal chloride should be handled with extreme caution. It is essential to store and handle it in a well-ventilated area, away from heat, sparks, and open flame to prevent accidents and ensure safety.

InChI:InChI=1/C7H5Cl2F/c8-7(9)5-2-1-3-6(10)4-5/h1-4,7H

Upstream product

• 352-70-5 m-Fluorotoluene 
• 456-42-8 m-fluorobenzyl chloride 
• 401-77-4 3-fluoro-1-(trichloromethyl)benzene 
• 456-48-4 3-Fluorobenzaldehyde 
• 456-47-3 3-fluoro-benzenemethanol 
• 18539-43-0 2-<3-Fluor-benzyloxy>-tetrahydro-pyran 
• 1333429-12-1 3-fluorobenzyl trimethylsilyl ether 

Downstream Products

• 26120-46-7 ((3-fluorophenyl)methylene)bis(trimethylsilane) 
• 455-34-5 1-(dibromomethyl)-3-fluorobenzene 
• 456-48-4 3-Fluorobenzaldehyde 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 720-22-9 1-<5-Fluor-2-nitrophenyl>-2-nitro-ethanol 
• 716-67-6 5-Fluor-2,ω-dinitro-styrol 
• 3094-46-0 5-Fluor-2-nitrobenzaldehyd-diacetat 

Relevant academic research and scientific papers

REDUKTION VON BENZOTRICHLORIDEN ZU BENZALCHLORIDEN

Benzal chlorides are prepared from the corresponding benzotrichlorides by reduction with thiophenol in the presence of catalytic amounts of copper(I) bromide.

One-pot, oxidative and selective conversion of benzylic silyl and tetrahydropyranyl ethers to gem-dichlorides using trichloroisocyanuric acid and triphenylphosphine as an efficient and neutral system

A one-pot and oxidative method is described for the first time for the conversion of benzylic trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers to gem-dichlorides using trichloroisocyanuric acid (TCCA) and triphenylphosphine (PPh3) in neutral media. Various theses substrates containing electron withdrawing or donating groups can be efficiently converted to their corresponding gem-dichlorides in good to excellent yields. The present method shows a high degree of chemoselectivity, and due to its one-pot nature is in accordance with green chemistry.

One-pot, selective and mild conversion of benzylic alcohols to gem -dichlorides using chlorodiphenylphosphine and 2,3-dichloro-5,6-dicyanobenzoquinone as a new and neutral system

A mild and one-pot conversion of benzylic alcohols to their corresponding gem-dichlorides is reported for the first time using chlorodiphenylphosphine (ClPPh2) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in dichloromethane under neutral conditions and at room temperature. The present method can be efficiently used for preparation of gem-dichlorides even in the presence of some other functional groups with excellent chemoselectivity.

A simple and efficient procedure for the preparation of benzal chlorides and benzal bromides

Benzal chlorides and benzal bromides were conveniently synthesized by reaction of aryl aldehydes with a Vilsmeier type reagent formed in situ by reduction of CCl4 or CBr4 in dimethylformamide (DMF) as solvent.

MECHANISMS OF FREE-RADICAL REACTIONS. XIII. MECHANISM AND SELECTIVITY OF THE FREE-RADICAL HALOGENATION OF ALKYL AROMATIC HYDROCARBONS WITH FLUOROALKYL SUBSTITUENTS

The free-radical chlorination and bromination of 1-fluoro-2-arylethanes and 1,1,1-trifluoro-2-arylethanes was studied by the method of competing reactions.In all cases a good correalation between log krel and the Brown ?+ constants was observed.The variation of the selectivity in the transition from one reaction series to the other indicates that two independent factors which determine the reactivity (the change in the dissociation energy of the C-H bond and the polar effect of the substituents) have a simultaneous effect.