40101-51-7

Basic information

• Product Name: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID
• Synonyms: ART-CHEM-BB B006489;IFLAB-BB F0777-0248;CHEMBRDG-BB 5135230;3-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC ACID;3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID;AKOS B006489;AKOS AU36-M175;AKOS BBS-00004711
• CAS NO: 40101-51-7
• Molecular Formula: C₁₅H₉NO₄
• Molecular Weight: 267.24
• Mol File: 40101-51-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 283-284 °C
• Boiling Point: 526.7°Cat760mmHg
• Flash Point: 272.4°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 6.35E-12mmHg at 25°C
• PKA: 4.04±0.10(Predicted)
• CAS DataBase Reference: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID(40101-51-7)
• EPA Substance Registry System: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID(40101-51-7)

Safety Data

• Hazardous Substances Data: 40101-51-7(Hazardous Substances Data)

Usage

General Description

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoic acid is a chemical compound with the molecular formula C16H9NO5. It is a derivative of isoindole and benzoic acid, and its structure consists of a benzoic acid group with a 1,3-dioxo-1,3-dihydro-isoindol-2-yl substituent. 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID is used in organic synthesis and pharmaceutical research, where it may have potential applications in the development of new drugs or materials. It is important to handle and store this chemical with care, as it may have potential hazards and should be used in a controlled laboratory environment.

InChI:InChI=1/C15H9NO4/c17-13-11-6-1-2-7-12(11)14(18)16(13)10-5-3-4-9(8-10)15(19)20/h1-8H,(H,19,20)/p-1

Upstream product

• 520-03-6 N-phenylphthalimide 
• 99-05-8 meta-aminobenzoic acid 
• 85-44-9 phthalic anhydride 
• 22774-11-4 m-benzylideneaminobenzoic acid 
• 136918-14-4 phthalimide 
• 4518-10-9 Methyl 3-aminobenzoate 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 84-66-2 Diethyl phthalate 
• 300667-12-3 methyl 3-(1,3-dioxoisoindolin-2-yl)benzoate 

Downstream Products

• 13280-60-9 5-amino-2-nitrobenzoic acid 
• 1202038-44-5 C₂₀H₁₃N₃O₃ 
• 1030650-62-4 C₂₀H₁₃N₃O₃ 
• 419539-34-7 C₂₁H₁₃FN₂O₃ 
• 314045-59-5 C₂₂H₁₆N₂O₄ 
• 313392-00-6 C₂₁H₁₃ClN₂O₃ 
• 389069-33-4 C₂₁H₁₄N₂O₄ 
• 885577-61-7 C₂₁H₁₄N₂O₄ 
• 1202038-43-4 C₂₃H₁₈N₂O₅ 
• 898120-99-5 C₁₈H₁₄N₂O₃ 
• 302953-44-2 C₂₁H₁₃FN₂O₃ 
• 925137-17-3 3-(1,3-dioxoisoindolin-2-yl)-N-(4-methoxybenzyl)benzamide ⁽⁵¹⁾. A solution of of 3-(1,3-dioxoisoindolin-2-yl)benzoic acid 

Relevant articles and documents

New phthalimide-benzamide-1,2,3-triazole hybrids; design, synthesis, α-glucosidase inhibition assay, and docking study

A new series of phthalimide-benzamide-1,2,3-triazole hybrids 8a–k as α-glucosidase inhibitors was designed and synthesized. The biological evaluation of compounds 8a–k against yeast α-glucosidase demonstrated that all they have excellent inhibitory activity in comparison with standard inhibitor acarbose. Among them, the most potent compound was compound 8d with inhibitory activity 18.5-fold more than acarbose. Kinetic study revealed that α-glucosidase inhibition of compound 8d was the competitive type. Furthermore, docking study suggested that compound 8d is more stable than acarbose in the active site of α-glucosidase.

Synthesis of phthalimides, isoindolin-1-ones and isoindolines bearing aminobenzoic acids as a new fluorescent compounds

Both experimental and theoretical methods were used in order to study the fluorescent properties of nine new compounds based on phthalimides, isoindolin-1-ones and isoindolines bearing aminobenzoic acids (2-aminobenzoic acid, 3-aminobenzoic acid and 4-aminobenzoic acid), which were obtained under mild reaction conditions. The photophysical properties of all the compounds were studied by electronic absorption and fluorescence spectroscopy in methanol solutions. All compounds exhibited fluorescence emission and high quantum yields. Additionally, it was found that the intramolecular charge in these donor-acceptor systems is significantly depending on electron-withdrawing substituents at the carboxylic acid position.

Amide compounds for regulating WNT signal channel and application of compounds

The invention belongs to the technical field of medicine, and particularly relates to amide compounds for regulating a WNT signal channel and an application of the compounds. The compounds have a structure represented by a general formula I shown in the description.