40106-82-9Relevant academic research and scientific papers
Discovery of new apoptosis-inducing agents for breast cancer based on ethyl 2-amino-4,5,6,7-tetra hydrobenzo[b]thiophene-3-carboxylate: Synthesis, in vitro, and in vivo activity evaluation
Barakat, Assem,Boraei, Ahmed T. A.,Eltamany, Elsayed H.,Gad, Emad M.,Hammad, Magdy S. A. G.,Nafie, Mohamed S.
, (2020/06/29)
A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[
Synthesis and antimicrobial activity of some tetramethylenethieno[2,3-d]pyrimidine derivatives
Ismail,Aboulwafa,Koreish
, p. 611 - 616 (2007/10/03)
A series of tetramethylenethieno[2,3-d]pyrimidine derivatives has been synthesized and tested for its antimicrobial properties. All the synthesized compounds were found to exhibit in vitro antibacterial and/or antifungal activity. The highest activity was elicited by 4-benzolhydrazino-5,6-tetramethylenethieno[2,3-d]pyrimidine (9) showing MIC value of 7.81 μg/ml against E. coli and C. albicans, while its MBC value was half that of nystatin. Compound 16 was almost as potent as nystatin exhibiting a minimum bactericidal concentration (MBC) value of 15.62 μg/ml.
Studies in the Synthesis and Interconversion of Isomeric Triazolothienopyrimidines
Shishoo, C. J.,Devani, M. B.,Ullas, G. V.,Anathan, S.,Bhadti, V. S.
, p. 43 - 46 (2007/10/02)
4-Hydrazinothienopyrimidines were cyclized with triethyl orthoformate and formic acid to give 1,2,4-triazolothienopyrimidines and 1,2,4-triazolothienopyrimidines depending on the reaction conditions employed.
