115012-09-4

Usage

Uses

Used in Pharmaceutical Development:
5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to modulate the activity of specific enzymes, which can lead to the development of new drugs targeting various diseases and conditions.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI) is used as a building block for the creation of novel agrochemicals, potentially enhancing crop protection and management strategies through its interaction with biological systems at the molecular level.
Used in Research Settings:
5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI) serves as a subject of study in research labs, where scientists investigate its pharmacological properties and potential therapeutic applications. This includes examining its interactions with biological systems and evaluating its efficacy and safety as a prospective drug candidate.

Upstream product

• 4664-00-0 2,3-pyridinedicarboximide 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 

Downstream Products

• 135128-27-7 7-(4-Bromo-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one 
• 135128-26-6 7-(2-Bromo-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one 
• 135128-23-3 7-(3,4-Dimethoxy-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one 
• 135128-25-5 7-(4-Methoxy-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one 
• 135128-43-7 6,7-dihydro-7-phenylsulfonyl-5H-pyrrolo<3,4-b>pyridin-5-one 
• 135128-20-0 7-(2,5-Dimethoxy-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one 
• 132033-48-8 6,7-Dihydro-7-phenyl-5H-pyrrolo<3,4-b>pyridin-5-one 
• 132033-58-0 4b-Phenyl-5,10-dihydro-4bH-4,10a-diaza-benzo[b]fluoren-11-one 
• 132033-57-9 10a-Phenyl-8,9,10,10a-tetrahydro-7H-pyrido[2,3-a]indolizin-5-one 
• 132033-56-8 9a-Phenyl-7,8,9,9a-tetrahydro-pyrido[2,3-a]pyrrolizin-5-one 
• 5657-51-2 7H-furo[3,4-b]pyridin-5-one 
• 135128-42-6 6,7-dihydro-7-(p-tolylthio)-5H-pyrrolo<3,4-b>pyridin-5-one 
• 115012-14-1 6,7-dihydro-7-amino-5H-pyrrolo<3,4-b>pyridin-5-one 
• 40107-93-5 6,7-dihydro-5H-pyrrolo<3,4-b>pyridin-5-one 

Relevant academic research and scientific papers

The Thermally-Controlled Chemoselective Reduction of 5H-Pyrrolopyridine-5,7(6H)-dione with Sodium Borohydride

The title reaction produced either 2-(hydroxymethyl)nicotinamide or 6,7-dihydro-7-hydroxy-5H-pyrrolopyridin-5-one as the major product at room temperature or -20 deg C, respectively, along with the corresponding regioisomers as minor products.These novel compounds were converted to known compounds in order to establish their isomeric structures.

Pyridine salt / 1,4-dihydropyridine derivative and preparation method thereof

The present invention discloses a pyridine salt / 1,4-dihydropyridine derivative (NAD / NADH analog) with novel structure. The NAD / NADH analog can substitute natural NAD / NADH to be applied to a biochemical system for redox reactions, and can also be used as an electron carrier for the energy transfer of an enzymatic fuel cell. Further, the NAD / NADH analogs provided by the invention are easy to prepare, isolate and purify, and have a high yield.

New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis

A new artificial fluoro-cofactor was developed for the replacement of natural cofactors NAD(P), exhibiting a high hydride transfer ability. More importantly, we established a new and fast screening method for the evaluation of the properties of artificial cofactors based on the fluorescence assay and visible color change.

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

Magnesium Ion Assisted Highly Regio- and Chemoselective Reduction of 5H-Pyrrolopyridine-5,7(6H)-diones with Sodium Borohydride. A Convenient Synthesis of 6,7-Dihydro-7-hydroxy-5H-pyrrolopyridin-5-ones

6-Substituted and unsubstituted 6,7-dihydro-7-hydroxy-5H-pyrrolopyridin-5-ones were predominantly obtained in excellent yield by the reduction of the corresponding 5,7-diones with sodium borohydride in the presence of Mg ion at 0 deg C.The highly r