40112-97-8

Upstream product

• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 100-39-0 benzyl bromide 
• 1443118-02-2 C₁₆H₁₈NO₂⁽¹⁺⁾*Br^(1-) 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Relevant academic research and scientific papers

Efficient and chemoselective reduction of pyridines to tetrahydropyridines and piperidines via rhodium-catalyzed transfer hydrogenation

Promoted by iodide anion the rhodium complex dimer, [Cp RhCl 2]2, catalyzes efficiently the transfer hydrogenation of various quaternary pyridinium salts under mild conditions, affording not only piperidines but also 1,2,3,6-tetrahydropyridines in a highly chemoselective fashion, depending on the substitution pattern at the pyridinium ring. The reduction is conducted in azeotropic formic acid/triethylamine (HCOOH-Et 3N) mixture at 40 °C, with catalyst loadings as low as 0.005mol% being feasible. Copyright