40116-81-2Relevant academic research and scientific papers
Asymmetric Synthesis of γ-Secondary Amino Alcohols via a Borrowing-Hydrogen Cascade
Chang, Xiaoyong,Chen, Fumin,He, Dongxu,Jin, Ming Yu,Pan, Yupeng,Xing, Xiangyou,You, Yipeng
, p. 7278 - 7283 (2020)
The borrowing-hydrogen (or hydrogen autotransfer) process, where the catalyst dehydrogenates a substrate and formally transfers the H atom to an unsaturated intermediate, is an atom-efficient and environmentally benign transformation. Described here is an example of an asymmetric borrowing-hydrogen cascade for the formal anti-Markovnikov hydroamination of allyl alcohols to synthesize optically enriched γ-secondary amino alcohols. By exploiting the Ru-(S)-iPrPyme catalyst with minimal stereogenicity, a cascade process including dehydrogenation, conjugate addition, and asymmetric reduction was developed. The mild conditions, functional group tolerance, and broad substrate scope (54 examples) demonstrate the synthetic practicality of the catalytic system.
COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS
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Page/Page column 125, (2019/04/26)
The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.
BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS
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Page/Page column 125, (2017/02/09)
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Asymmetric Synthesis. Part 6. Asymmetric Reduction of Aminoketones with (-)-Bornan-2-exo-yloxyaluminium Dichloride
Samaddar, Ashis K.,Konar, Samir K.,Nasipuri, Dhanonjoy
, p. 1449 - 1451 (2007/10/02)
α-Dialkylaminoacetophenones and β-dialkylaminopropiophenones have been reduced asymmetrically with (-)-bornan-2-exo-yloxyaluminium dichloride to the corresponding aminoalcohols in 58-92percent enantiomeric excess.The absolute configurations of the predomi
