40135-88-4Relevant academic research and scientific papers
METHODS FOR TREATMENT OF RESISTANT CANCER
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, (2017/11/16)
The present disclosure describes a method to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds of the invention can decrease the rate of proliferation of drug-resistant cancer cells, such as glioma,
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
Henry, Sean,Kidner, Ria,Reisenauer, Mary R.,Magedov, Igor V.,Kiss, Robert,Mathieu, Véronique,Lefranc, Florence,Dasari, Ramesh,Evidente, Antonio,Yu, Xiaojie,Ma, Xiuye,Pertsemlidis, Alexander,Cencic, Regina,Pelletier, Jerry,Cavazos, David A.,Brenner, Andrew J.,Aksenov, Alexander V.,Rogelj, Snezna,Kornienko, Alexander,Frolova, Liliya V.
, p. 313 - 328 (2016/06/01)
Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridin
Synthesis of Amaryllidaceae alkaloids, siculine, oxocrinine, epicrinine, and buflavine
Kodama, Sumiaki,Takita, Hirofumi,Kajimoto, Tetsuya,Nishide, Kiyoharu,Node, Manabu
, p. 4901 - 4907 (2007/10/03)
Three crinane type of alkaloids isolated from Amaryllidaceae family were synthesized by taking advantage of the PIFA-mediated intramolecular p-p′ diphenol coupling reaction of norbelladine derivatives. Furthermore, buflavine was also prepared by using the p-p′ diphenol coupling followed by dienone-phenol rearrangement as a key step.
