40137-41-5

Usage

Uses

Used in Organic Synthesis:
[1-(4-chlorophenyl)ethylidene]hydrazine is used as a reagent in the field of organic synthesis for the preparation of other hydrazine derivatives. Its unique structure allows for the creation of a variety of complex molecules, making it a valuable tool in the development of new chemical compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [1-(4-chlorophenyl)ethylidene]hydrazine is investigated for its potential applications, including its demonstrated anti-inflammatory and anticancer properties. Researchers are exploring its use in the development of new drugs to treat various diseases, particularly cancer.
Used in Pesticide Development:
[1-(4-chlorophenyl)ethylidene]hydrazine has been found to exhibit insecticidal and larvicidal activities, indicating its potential as a candidate for the development of new pesticides. This application could lead to the creation of more effective and environmentally friendly pest control solutions.
Safety Precautions:
Due to the potential toxicity and reactivity of [1-(4-chlorophenyl)ethylidene]hydrazine, proper handling and disposal procedures are essential when working with [1-(4-chlorophenyl)ethylidene]hydrazine. This ensures the safety of individuals and the environment during its use in research and development.

Upstream product

• 1956-39-4 (E)-1-(4-chlorophenyl)ethanone oxime 
• 99-91-2 para-chloroacetophenone 
• 5757-81-3 4-Chlor-acetophenon- 

Downstream Products

• 1126-46-1 Methyl 4-chlorobenzoate 
• 99-91-2 para-chloroacetophenone 
• 89752-33-0 7-(4-Chloro-phenyl)-7-methyl-2,3a,5-triphenyl-3,3a-dihydro-pyrazolo[1,5-c][1,3]oxazine 
• 61185-76-0 1-(p-chlorophenyl)-1-diazoethane 
• 74-11-3 para-chlorobenzoic acid 
• 93900-78-8 1-chloro-4-[2-(4-chlorophenyl)-1-methylprop-1-enyl]benzene 
• 127042-57-3 1-(1,1-dibromoprop-1-en-2-yl)-4-chlorobenzene 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 56587-85-0 1,2-bis[1-(4-chlorophenyl)ethylidene]hydrazine 
• 93900-78-8 cis-4.4'-Dichlor-α.α'-dimethyl-stilben 
• 1103647-01-3 C₁₁H₁₃ClN₄*ClH 
• 5406-33-7 4-chlorobenzyl acetate 
• 20386-93-0 4-chlorobenzyl benzoate 
• 1198575-42-6 1-methyl-3,4-diphenyl-6-chloro-isoquinoline 

Relevant academic research and scientific papers

Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallograph

Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes

A highly enantioselective synthesis of trisubstituted allenes has been achieved through Cu(I)-catalyzed cross-coupling of aryldiazoalkanes and terminal alkynes with chiral bisoxazoline ligands. Alkynyl migratory insertion of Cu(I) carbene is proposed as t

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups. Well tolerated: A mild copper-catalyzed coupling reaction between unstabilized diazo compounds (generated in flow) and terminal alkynes is reported. The method provides di- and trisubstituted allenes with high functional-group tolerance.

Regioselective one-step synthesis of pyrazoles from alkynes and N-tosylhydrazones: [3+2] dipolar cycloaddition/[1,5] sigmatropic rearrangement cascade

Rearrangement under control: A wide variety of 3,4,5- and 1,3,5-trisubstituted pyrazoles can be prepared from tosylhydrazones of ketones and terminal alkynes through the title reaction sequence (see scheme; Ts=4-toluenesulfonyl). The rearrangement, and th

Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives

A series of N-(imidazolidin-2-ylidene)hydrazones and N-(4,5-dihydro-1H- imidazol-2-yl)-N-methylhydrazones were prepared and examined for α1-, α2-adrenergic and imidazoline I 1, I2 receptors binding affinities as well as cytotoxic activity against human tumor cell lines. Among the compounds tested, 2-naphthaldehyde N-(imidazolidin-2-ylidene)hydrazone (3e) exhibited a significant affinity for both α2-adrenergic and imidazoline I1 receptors (Ki = 94.3 nM and IC50 = 51.7 nM, respectively). Moreover, pyridine-2-carboxaldehyde N-(imidazolidin-2-ylidene) hydrazone (3l) showed the highest binding affinity to α1- adrenoceptors (Ki = 24.6 nM), while quinoline-2-carboxaldehyde N-(imidazolidin-2-ylidene)hydrazone (3m) displayed the highest I2 affinity with a Ki value of 26.7 nM and a high selectivity with respect to α2-adrenergic and imidazoline I1 receptors (Ki = 22470.0 nM and IC50 = 6145.0 nM, respectively). None of the tested N-(4,5-dihydro-1H-imidazol-2-yl)-N- methylhydrazones 4p-u displayed cytotoxic activity.

Reductive deoximation of aryloximes into hydrocarbons by hydrazine/KOH: A novel application of the wolff-kishner reduction

We report the reductive deoximation of different substituted aryl, diaryl, and aralkyloximes into the respective methyl or methylene derivatives by hydrazine hydrate/KOH at reflux in satisfactory yields. Copyright Taylor & Francis Group, LLC.

The catalytic olefination reaction of aldehydes and ketones with CBr 3CF3

The new approach of catalytic olefination reaction (COR) has been used to convert aromatic and aliphatic aldehydes and ketones to 2-bromo-3,3,3- trifluoroprop-1-enes by the treatment of corresponding hydrazones with CBr 3CF3 under copper(I) catalysis conditions. The reaction proceeds stereoselectively, the target alkenes were obtained in good yields.

A novel transformation of oximes into hydrazones by hydrazine hydrate

We report a novel transformation of different substituted aryl, diaryl, and aralkyloximes into the respective hydrazones using hydrazine hydrate in ethanol at reflux in excellent yields.

A convenient method for the preparation of N-unsubstituted hydrazones of aromatic ketones and aldehydes

A general and useful method for the synthesis of N-unsubstituted hydrazones of aromatic ketones and aldehydes in good yields was elaborated. The use of a large excess of hydrazine hydrate and catalytic amounts of p-toluenesulfonic acid makes it possible to prepare the hydrazones without an admixture of the corresponding azine.