2,5-bis(aziridin-1-yl)-3,6-diethoxycyclohexa-2,5-diene-1,4-dione, commonly known as BCNU, is a potent alkylating agent that serves as a chemotherapy drug. It is characterized by its ability to crosslink DNA, thereby inhibiting the replication and transcription processes within cancer cells, which results in cell death. BCNU is administered intravenously and has a relatively long half-life, providing a sustained anti-cancer effect.
4014-60-2
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Basic information
- Product Name: 2,5-bis(aziridin-1-yl)-3,6-diethoxycyclohexa-2,5-diene-1,4-dione
- Synonyms:
- CAS NO:4014-60-2
- Molecular Formula: C14H18N2O4
- Molecular Weight: 278.3037
- EINECS: N/A
- Product Categories: N/A
- Mol File: 4014-60-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 446.2°C at 760 mmHg
- Flash Point: 223.7°C
- Appearance: N/A
- Density: 1.33g/cm3
- Vapor Pressure: 3.7E-08mmHg at 25°C
- Refractive Index: 1.596
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2,5-bis(aziridin-1-yl)-3,6-diethoxycyclohexa-2,5-diene-1,4-dione(CAS DataBase Reference)
- NIST Chemistry Reference: 2,5-bis(aziridin-1-yl)-3,6-diethoxycyclohexa-2,5-diene-1,4-dione(4014-60-2)
- EPA Substance Registry System: 2,5-bis(aziridin-1-yl)-3,6-diethoxycyclohexa-2,5-diene-1,4-dione(4014-60-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 4014-60-2(Hazardous Substances Data)
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4014-60-2 Usage
Uses
Used in Oncology:BCNU is used as a chemotherapeutic agent for the treatment of various types of cancer, including brain tumors, Hodgkin's disease, and multiple myeloma. Its mechanism of action involves the crosslinking of DNA, which prevents the replication and transcription of genetic material in cancer cells, ultimately leading to their death.
Used in Cancer Treatment:
In the medical field, BCNU is utilized as an anti-cancer drug to combat malignancies. Its alkylating properties allow it to create covalent bonds with DNA, disrupting the normal function and replication of cancer cells, which is crucial for controlling tumor growth and spread.
However, due to its potential to cause severe side effects such as bone marrow suppression, gastrointestinal issues, and possible damage to the heart and lungs, the use of BCNU is carefully monitored and managed by healthcare professionals to ensure patient safety and optimize therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 4014-60-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,1 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.Calculate Digit Verification of CAS Registry Number 4014-60:
(6*4)+(5*0)+(4*1)+(3*4)+(2*6)+(1*0)=52
52 % 10 = 2
So 4014-60-2 is a valid CAS Registry Number.
4014-60-2Upstream product
4014-60-2Downstream Products
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2,5-bis(aziridin-1-yl)-3,6-diethoxycyclohexa-2,5-diene-1,4-dione
