40142-71-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-benzenethiophene-2-carboxylic acid is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its presence in the molecular structure of these compounds contributes to their therapeutic effects.
Used in Organic Compounds Synthesis:
3-Amino-benzenethiophene-2-carboxylic acid is used as a key intermediate in the production of other organic compounds, facilitating the creation of a wide range of chemical products.
Used in Anti-inflammatory Applications:
3-Amino-benzenethiophene-2-carboxylic acid is used as an anti-inflammatory agent, leveraging its chemical properties to help reduce inflammation and alleviate symptoms associated with various conditions.
Used in Antifungal Applications:
3-Amino-benzenethiophene-2-carboxylic acid is used as an antifungal agent, exhibiting properties that help combat fungal infections and support treatment for affected individuals.
Used in Disease Treatment Research:
3-Amino-benzenethiophene-2-carboxylic acid is used in research for its potential application in the treatment of several diseases, as its unique structure and properties are being studied for their therapeutic potential.

InChI:InChI=1/C9H7NO2S/c10-7-5-3-1-2-4-6(5)13-8(7)9(11)12/h1-4H,10H2,(H,11,12)

Upstream product

• 34761-09-6 ethyl 3-aminobenzothiophene-2-carboxylate 
• 35212-85-2 3-Amino-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 873-32-5 2-Chlorobenzonitrile 
• 98589-44-7 (2-cyano-phenylsulfanyl)-acetic acid 

Downstream Products

• 520-72-9 3-hydroxybenzothiophene 
• 191031-07-9 3-hydroxy-benzo[b]thiophene-2-carboxylic acid 
• 40139-63-7 2-methyl-3-phenyl-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one 
• 40139-65-9 3-methyl-2-phenyl-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one 
• 40139-64-8 2-phenyl-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one 
• 40139-60-4 2-phenyl-benzo[4,5]thieno[3,2-d][1,3]oxazin-4-one 

Relevant academic research and scientific papers

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the “Malaria Box”. After analysis of the data set, we have carried out a medicinal chemistry campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported.

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound selected from a group consisting of a compound represented by the following Formula (1): and an agriculturally acceptable salt thereof, provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (5) and an agriculturally acceptable salt thereof is excluded: (1) 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (2) 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (3) 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (4) 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, and (5) Benzo[b]thiophene-2-carboxylic acid.