4015-30-9Relevant academic research and scientific papers
Silver-Catalyzed Isocyanide Insertion into N?H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives
Zhang, Lingjuan,Li, Juanjuan,Hu, Zhongyan,Dong, Jinhuan,Zhang, Xian-Ming,Xu, Xianxiu
, p. 1938 - 1942 (2018/04/02)
A silver-catalyzed [5+1] annulation of o-acylaryl isocyanides with ammonium acetate and hydroxlamine was developed for the efficient and practical synthesis of quinazolines and quinazoline 3-oxides in good to excellent yields, respectively. The domino process involved an unprecedented isocyanide insertion into the N?H bond of ammonia or hydroxylamine and followed by condensation reaction at ambient conditions. (Figure presented.).
