401571-90-2Relevant academic research and scientific papers
Synthesis of fused 1,2,4-thiadiazolines by intramolecular cycloaddition-elimination reactions of 4-methyl-5-(cyano tethered)imino-Δ2-1,2,3,4-thiatriazolines
L'abbe,Leurs
, p. 7505 - 7518 (1992)
A series of 5-imino-1,2,3,4-thiatriazolines, bearing a cyano tether at the imine function, were prepared and converted into fused 1,2,4-thiadiazole derivatives by thermolysis; these are 12a→13, 20a→21, 20b→22 and 29→30 (Schemes 2-5). In one case, the precursor thiatriazole also underwent an intramolecular cycloaddition-elimination reaction to give a fused 1,2,4-thiadiazole; namely 17a→18. Thiatriazoline 33, with an aryl group attached directly to the imine function, thermolyzed to the benzothiazole 34.
Intramolecular Cycloaddition-Elimination Reactions of 4-Methyl-5-(substituted)-imino-Δ2-1,2,3,4-thiatriazolines
L'abbe, Gerrit,Leurs, Stefan
, p. 181 - 182 (2007/10/02)
4-Methyl-1,2,3,4-thiatriazolin-5-imines, bearing a cyanopropyl, o-cyanobenzyl or o-(cyanomethyl)benzyl group at the exocyclic imine function, thermolyse smoothly to give, after loss of nitrogen, fused 1,2,4-thiadiazole derivatives 7, 11 and 12.
