401801-44-3 Usage
Piperazine derivative
A chemical compound derived from piperazine
This means that the compound is structurally related to piperazine, a heterocyclic amine with various applications in the pharmaceutical industry.
Phenoxyethyl group
A functional group attached to the piperazine ring
The presence of this group in the structure of the compound contributes to its potential applications and makes it a valuable building block for the synthesis of other complex organic molecules.
Potential applications
Pharmaceuticals, agrochemicals, and materials science
The compound may have uses in various industries due to its unique structure and properties.
Organic chemistry
A field of chemistry focused on the study of organic compounds
The compound's chemical properties and potential uses make it an interesting subject for further research and development in this field.
Synthesis
The process of creating complex organic molecules from simpler ones
The presence of the phenoxyethyl group in the compound's structure makes it a potentially important building block for the synthesis of other complex organic molecules.
Heterocyclic amine
A type of organic compound containing a nitrogen atom in a ring structure
Piperazine, from which the compound is derived, is an example of a heterocyclic amine. This classification provides insight into the compound's chemical properties and potential reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 401801-44-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,1,8,0 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 401801-44:
(8*4)+(7*0)+(6*1)+(5*8)+(4*0)+(3*1)+(2*4)+(1*4)=93
93 % 10 = 3
So 401801-44-3 is a valid CAS Registry Number.
401801-44-3Relevant academic research and scientific papers
Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I)
Guo, Xiaoke,Ma, Xianglei,Yang, Qian,Xu, Jing,Huang, Lu,Jia, Jianmin,Shan, Jiaojiao,Liu, Li,Chen, Weilin,Chu, Hongxi,Wei, Jinlian,Zhang, Xiaojin,Sun, Haopeng,Tang, Yiqun,You, Qidong
supporting information, p. 89 - 94 (2014/06/09)
Kv1.5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation (AF), the most common arrhythmia that threatens human. Herein, by modifying the hit compound 7k from an in-house database, 48 derivatives were synthesized for the assay of their Kv1.5 inhibitory effects by whole cell patch clamp technique. Six compounds which showed better potency than the positive compound dronedarone were selected for the next evaluation of their drug-like properties. Compound 8 exhibited balanced solubility and permeability. It also showed acceptable pharmacodynamics profile with very low acute toxicity. Taking all these data into account, compound 8 can serve as a promising lead for the development of novel therapeutic agent for the treatment of AF.
