40182-17-0Relevant academic research and scientific papers
9,10-anthraquinone compound, pharmaceutically-acceptable salts and pharmaceutical application thereof
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, (2019/10/22)
The invention belongs to the field of pharmaceutical chemistry and relates to a 9,10-anthraquinone compound and a pharmaceutical application thereof, in particular to the 9,10-anthraquinone compound and the application thereof in the preparation of a phosphoglycerate mutase inhibitor and in the preparation of drugs for treating cancer. In particular, the invention discloses the application of the9,10-anthraquinone compound shown in the structure of a formula I, pharmaceutically-acceptable salts thereof, or a pharmaceutical composition taking the 9,10-anthraquinone compound as an effective active ingredient in preparing drugs for preventing and treating tumors. The compound can inhibit phosphoglycerate mutase activity and reduce cell metabolism level, and can be used for treating diseasessuch as solid tumors and blood tumors, and the tumors involved are pancreatic cancer, lung cancer, liver cancer, gastric cancer, esophageal cancer, intestinal cancer, breast cancer, cervical cancer, leukemia and melanoma.
A practical regiospecific synthesis of ortho- and meta-hydroxybenzenesulfonic acids
Babin, P.,Bennetau, B.,Bourgeois, P.,Rajarison, F.,Dunogues, J.
, p. 25 - 28 (2007/10/02)
The first regiospecific route to the ortho-hydroxybenzenesulfonic acid and competitive way to its meta regioisomer are reported.Both compounds were obtained from the silylation of the corresponding chlorophenols, followed by sulfonation of the arylsilane intermediates.Keywords: silylation / sulfonation / chlorophenols / hydroxybenezensulfonic acids
