18036-83-4

Usage

Uses

Used in Organic Synthesis:
Trimethyl2-[(trimethylsilyl)oxy]phenylsilane is used as a silylating agent for the protection of alcohols and phenols in organic synthesis. It helps prevent unwanted reactions at these functional groups, allowing for selective reactions to occur elsewhere in the molecule.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, trimethyl2-[(trimethylsilyl)oxy]phenylsilane is used as a protecting group in the synthesis of complex organic molecules, such as drugs and drug candidates. Its ability to protect alcohols and phenols allows for the selective introduction of various functional groups, facilitating the synthesis of desired compounds.
Used in Agrochemical Industry:
Trimethyl2-[(trimethylsilyl)oxy]phenylsilane is used in the agrochemical industry for the synthesis of various agrochemicals, such as pesticides and herbicides. Its use as a protecting group allows for the selective introduction of functional groups, enabling the production of effective and targeted agrochemicals.
Used in Materials Science:
In materials science, trimethyl2-[(trimethylsilyl)oxy]phenylsilane is used in the modification and functionalization of organic molecules, as well as in the production of various silicone-based materials. Its versatility allows for the development of new materials with improved properties, such as enhanced stability, durability, and performance.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 17881-65-1 (2-chlorophenoxy)trimethylsilane 
• 108-95-2 phenol 
• 95-56-7 2-hydroxybromobenzene 
• 1825-62-3 ethyl trimethylsilyl ether 

Downstream Products

• 15288-53-6 o-(trimethylsilyl)phenol 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 101-84-8 diphenylether 
• 1253786-03-6 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole 
• 1276113-19-9 2-(trimethylsilyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 141765-59-5 o-acetoxybenzenesulfonate de trimethylsilyle 
• 40182-17-0 chlorure d'o-acetoxybenzenesulfonyle 
• 609-46-1 phenol-2-sulfonic acid 
• 497180-95-7 O-(2-trimethylsilylphenyl)-N,N-dimethylaminothiocarbamate 
• 497180-98-0 S-(2-trimethylsilylphenyl)-N,N-dimethylaminothiocarbamate 
• 33356-45-5 2-(Trimethylsilyl)benzenethiol 

Relevant academic research and scientific papers

2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors

Stable 2-(trimethylsilyl)phenyl trimethylsilyl ethers, readily obtained from the corresponding halogenated phenols in two steps, were identified as novel benzyne precursors. These species were converted to benzynes by a domino reaction of O-desilylation,

Improved synthesis of the benzyne precursor 2-(trimethylsilyl)phenyl trifluoromethanesulfonate

An alternate procedure for the preparation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate, a coveted benzyne precursor, is described. Modifications to existing methods result in a dramatic reduction in the overall reaction time and eliminate the us

Interaction of alkoxides. XVIII. Utilitization of the complex base from alkyllithium and potassium alkoxides in the dimetallation of phenol, thiophenol, o-, m- and p-cresol

Successful O- and ortho-ring metallation of phenol and side chain metallation in o-cresol has been achieved by use of a mixture of two molar equivalents of n-butyllithium, one molar equivalent of potassium t-butoxide and two molar equivalents of N,N,N',N'-tetramethylethylene diamine in hexane.Poor results were obtained with m-cresol, thiophenol and p-cresol. m-Cresol was effectively dimetallated with a mixture of two molar equivalents of tBuOK and two molar equivalents of nBuLi*TMEDA.The effectiveness of another type of complex base based on 2-ethylhexyllithium (EhexLi) and potassium alkoxides has been also investigated, especially in respect of the influence of the concentration and the ctructure of the alkoxide used.With a complex base from EhexLi and 3 equivalents of potassium 3-methyl-3-pentoxide phenol was successfuly dimetallated even in the absence of TMEDA.Thus, the enhanced reactivity of a complex base containing a higher concentration of a more branched potassium alkoxide over that of previously used complex bases has been confirmed.

Reactions of o-Lithio-lithiumphenolate and o-Lithio-N-methyl-lithiumanilide with Halides of Phosphorus, Arsenic and Silicon

The title compounds and chlorides of the type ClERn (E=P, As, Si) react smoothly in a molecular ratio of 1:2 to give the corresponding disubstituted phenole and N-methylaniline derivatives, respectively.Attempts with an 1:1 ratio show different results de