401901-41-5Relevant academic research and scientific papers
CLIPTAC COMPOSITION
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Page/Page column 30; 84, (2018/01/17)
This invention relates to proteolysis targeting chimeric molecules formed from the intracellular self-assembly of precursors via bioorthogonal click chemistry (CLIPTACs), as well as related precursor compositions, methods and therapeutic applications.
Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids
Shirahata, Tatsuya,Sunazuka, Toshiaki,Yoshida, Kiminari,Yamamoto, Daisuke,Harigaya, Yoshihiro,Kuwajima, Isao,Nagai, Takayuki,Kiyohara, Hiroaki,Yamada, Haruki,Omura, Satoshi
, p. 9483 - 9496 (2007/10/03)
Pinellic acid from the tuber of Pinellia ternate, an active herbal component of the traditional Japanese herbal (Kampo) medicine Sho-seiryu-to, is a C18 trihydroxy fatty acid whose absolute stereochemistry has now been determined. All stereoisomers of pinellic acid were synthesized via regioselective asymmetric dihydroxylation, regioselective inversion, and stereoselective reduction in order to determine their absolute stereochemistries and adjuvant activities. Among this series of isomers, the (9S,12S,13S)-compound, which is a natural product, exhibited the most potent adjuvant activity. Spectral data for all of the stereoisomers of the 1,2-allylic diols were compared and related to their stereochemistries.
VACCINE PREPARATION CONTAINING FATTY ACID AS COMPONENT
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, (2008/06/13)
The present invention provides an adjuvant that is a hydroxy unsaturated fatty acid or a derivative thereof, as well as a vaccine preparation containing the adjuvant as a constituent. For example, a vaccine shows sufficient activity to enhance the immunity when a hydroxy unsaturated fatty acid having the following structure is administered:
Total synthesis of pinellic acid, a potent oral adjuvant for nasal influenza vaccine. Determination of the relative and absolute configuration
Sunazuka, Toshiaki,Shirahata, Tatsuya,Yoshida, Kiminari,Yamamoto, Daisuke,Harigaya, Yoshihiro,Nagai, Takayuki,Kiyohara, Hiroaki,Yamada, Haruki,Kuwajima, Isao,Omura, Satoshi
, p. 1265 - 1268 (2007/10/03)
Pinellic acid (1), isolated from a medicinal plant Pinelliae tuber, has potent adjuvant activity. The absolute configuration of pinellic acid was expected by derivatization of this compound and CD exciton chirality method. A convergent synthetic route to pinellic acid has been developed via regioselective asymmetric dihydroxylation and stereoselective reduction. The absolute configuration of pinellic acid was determined to be 9S,12S,13S, by comparing with the spectra data of natural and synthetic compounds.
