40195-48-0

Upstream product

• 40195-39-9 1-(Cyclohexylidene-trimethylsilanyloxy-methyl)-cyclohexanecarboxylic acid methyl ester 
• 67-56-1 methanol 
• 950-21-0 dispiro[5.1.5.1]tetradecane-7,14-dione 
• 3196-23-4 methyl 1-bromocyclohexanecarboxylate 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 40195-26-4 1-methoxy-1-trimethylsilyloxymethylenecyclohexane 

Downstream Products

• 361363-97-5 methyl 1-(1-bromocyclohexylcarbonyl)cyclohexanecarboxylate 

Relevant academic research and scientific papers

Synthesis of 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones by reformatsky reaction

Abstract Methyl 1-bromocyclohexanecarboxylate reacted with zinc and aromatic aldehydes in two steps to afford 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones; methyl 1-[aryl(hydroxy)methyl]cyclohexanecarboxylates were also formed as by-products.

Reformatsky synthesis of 16-aryl-15-oxadispiro[5.1.5.3]-hexadecane-7,14-diones

Methyl 1-bromocyclohexanecarboxylate reacts with zinc in the presence of cyclohexanecarbonyl chloride to give methyl 1-(cyclohexylcarbonyl)cyclohexanecarboxylate. Treatment of the latter with bromine leads to formation of methyl 1-(1-bromocyclohexylcarbonyl)cyclohexanecarboxylate which reacts with zinc and aromatic aldehydes, yielding 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones.