4021-75-4

Usage

Uses

Used in Organic Synthesis:
2,3-dibromobutan-1-ol is used as an intermediate for the synthesis of other organic compounds. Its unique structure allows it to be a valuable building block in the creation of various chemical products.
Used in Organic Chemistry Reactions:
2,3-dibromobutan-1-ol is used as a reagent in organic chemistry reactions. Its presence can facilitate or enhance the reactions, leading to the desired products with improved efficiency and selectivity.
Used in Chemical Research:
2,3-dibromobutan-1-ol is utilized in chemical research to study the properties and reactions of brominated compounds. This can contribute to the development of new synthetic methods and the understanding of reaction mechanisms.
Used in Pharmaceutical Industry:
2,3-dibromobutan-1-ol is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique structure can be exploited to create new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2,3-dibromobutan-1-ol is used in the development of agrochemicals, such as pesticides and herbicides. Its reactivity and functional groups can be utilized to create effective and targeted agrochemical products.
Used in Dye and Pigment Industry:
2,3-dibromobutan-1-ol is used in the synthesis of dyes and pigments. Its bromine-containing structure can contribute to the color and stability of these products, making them suitable for various applications, such as textiles, plastics, and paints.
Used in Specialty Chemicals:
2,3-dibromobutan-1-ol is used in the production of specialty chemicals, such as flame retardants, surfactants, and polymer additives. Its unique properties can enhance the performance and characteristics of these chemicals, making them valuable in various industries.

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 6117-91-5 (E/Z)-2-buten-1-ol 
• 504-61-0 (E)-but-2-enol 
• 4088-60-2 cis-2-buten-1-ol 
• 4021-75-4 (2R*,3R*)-2,3-dibromobutan-1-ol 

Downstream Products

• 600-30-6 erythro-2,3-dibromobutanoic acid 
• 632-05-3 1,2,3-tribromobutane 
• 52467-65-9 (Z)-2-bromobut-2-en-1-ol 
• 6117-91-5 (E/Z)-2-buten-1-ol 
• 4021-75-4 (–)-(2S,3S)-2,3-dibromobutan-1-ol 
• 4021-75-4 threo-2,3-Dibrombutan-1-ol 

Relevant academic research and scientific papers

COMPOUNDS USEFUL IN INHIBITING KETOHEXOKINASE AND METHODS OF MAKING AND USING THE SAME

The present invention relates to compounds that can act as inhibitors of ketohexokinase (KHK) and that can be useful in the treatment of diseases and/or disorders associated with KHK. In some embodiments, the present invention relates to compounds and com

Molecular Recognition and Cocrystallization of Methylated and Halogenated Fragments of Danicalipin A by Enantiopure Alleno-Acetylenic Cage Receptors

Enantiopure (P)4- and (M)4-configured alleno-acetylenic cage (AAC) receptors offer a highly defined interior for the complexation and structure elucidation of small molecule fragments of the stereochemically complex chlorosulfolipid danicalipin A. Solution (NMR), solid state (X-ray), and theoretical investigations of the formed host-guest complexes provide insight into the conformational preferences of 14 achiral and chiral derivatives of the danicalipin A chlorohydrin core in a confined, mostly hydrophobic environment, extending previously reported studies in polar solvents. The conserved binding mode of the guests permits deciphering the effect of functional group replacements on Gibbs binding energies ΔG. A strong contribution of conformational energies toward the binding affinities is revealed, which explains why the denser packing of larger apolar domains of the guests does not necessarily lead to higher association. Enantioselective binding of chiral guests, with energetic differences ΔΔG293 K up to 0.7 kcal mol-1 between diastereoisomeric complexes, is explained by hydrogen- and halogen-bonding, as well as dispersion interactions. Calorimetric studies (ITC) show that the stronger binding of one enantiomer is accompanied by an increased gain in enthalpy ΔH but at the cost of a larger entropic penalty TΔS stemming from tighter binding.

DISUBSTITUTED PYRAZOLE COMPOUNDS

The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and no

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fructose-1

SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS

Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (-)-Deschloromytilipin A and (-)-Danicalipin A

A titanium-based catalytic enantioselective dichlorination of simple allylic alcohols is described. This dichlorination reaction provides stereoselective access to all common dichloroalcohol building blocks used in syntheses of chlorosulfolipid natural products. An enantioselective synthesis of ent-(-)-deschloromytilipin A and a concise, eight-step synthesis of ent-(-)-danicalipin A are executed and employ the dichlorination reaction as the first step. Extension of this system to enantioselective dibromination and its use in the synthesis of pentabromide stereoarrays relevant to bromosulfolipids is reported. The described dichlorination and dibromination reactions are capable of exerting diastereocontrol in complex settings allowing X-ray crystal structure analysis of natural and unnatural diastereomers of polyhalogenated stereohexads.

Constructing the architecturally distinctive ABD-tricycle of phomactin A through an intramolecular oxa-[3+3] annulation strategy

Our efforts in constructing the ABD-ring of phomactin A through an intramolecular oxa-[3+3] annulation strategy is described. This struggle entailed finding a practical and efficient preparation of annulation precursor, and a realization of the unexpected competing regioisomeric pathway. The success entailed accessing the A-ring through Diels-Alder cycloaddition of Rawal's diene. Furthermore, the discovery that the regioisomers from the annulation existed as atropisomers with respect to the D-ring olefin and that they could be equilibrated to the desired ABD-tricycle, allowing large quantities of tricycle to be accessed.

Organocatalytic diastereoselective dibromination of alkenes

A highly diastereoselective pyrrolidine-promoted dibromination of alkenes by combination of NBS and succinimide is presented. The pyrrolidine-mediated dibromination of alkenes is higly anti-selective and gives the corresponding products in moderate to high yields and up to >25:1 dr.

An asymmetric total synthesis of brevisamide

An enantioselective synthesis of marine alkaloid brevisamide was accomplished in a convergent manner. The synthesis utilized an enantioselective hetero-Diels - Alder reaction which sets three chiral centers in compound 11. The synthesis also features a modified Wolff-Kishner reduction, Rubottom oxidation, and Suzuki - Miyaura coupling to furnish brevisamide.

Substituted Azetidine compounds, their preparation and use as medicaments

The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals