40218-96-0 Usage
Chemical structure
The compound consists of a piperazine ring with a cinnamyl group attached at the 4-position and two 4-fluorophenylmethyl groups attached to the nitrogen atom of the piperazine ring.
Classification
It falls into the category of piperazine derivatives, which are known for their diverse pharmacological properties.
Use as a reference standard
1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine is commonly used as a reference standard for analytical purposes in the field of pharmaceutical research and drug development.
Potential therapeutic applications
The compound has been studied for its potential therapeutic applications, particularly in the field of neurological and psychiatric disorders.
Unique chemical structure
The compound's unique chemical structure and biological activity make it a promising candidate for further research and development in the pharmaceutical industry.
Biological activity
The compound's biological activity is attributed to its interaction with various receptors and neurotransmitter systems in the body, which may contribute to its potential therapeutic effects.
Research focus
Further research is needed to fully understand the compound's mechanism of action, safety, and efficacy in treating neurological and psychiatric disorders.
Synthesis
The synthesis of 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine involves the formation of the piperazine ring and the subsequent attachment of the cinnamyl and 4-fluorophenylmethyl groups.
Analytical techniques
Various analytical techniques, such as mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, and high-performance liquid chromatography (HPLC), can be used to characterize and analyze the compound.
Regulatory status
The regulatory status of 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine may vary depending on the country and its intended use (e.g., research, therapeutic, or recreational). It is essential to comply with local regulations and guidelines when working with this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 40218-96-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,2,1 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 40218-96:
(7*4)+(6*0)+(5*2)+(4*1)+(3*8)+(2*9)+(1*6)=90
90 % 10 = 0
So 40218-96-0 is a valid CAS Registry Number.
40218-96-0Relevant articles and documents
Platinum-catalyzed direct amination of allylic alcohols under mild conditions: Ligand and microwave effects, substrate scope, and mechanistic study
Ohshima, Takashi,Miyamoto, Yoshiki,Ipposhi, Junji,Nakahara, Yasuhito,Utsunomiya, Masaru,Mashima, Kazushi
experimental part, p. 14317 - 14328 (2010/02/16)
Transition metal-catalyzed amination of allylic compounds via a π-allylmetal intermediate is a powerful and useful method for synthesizing allylamines. Direct catalytic substitution of allylic alcohols, which forms water as the sole coproduct, has recently attracted attention for its environmental and economical advantages. Here, we describe the development of a versatile direct catalytic amination of both aryl- and alkyl-substituted allylic alcohols with various amines using Pt-Xantphos and Pt-DPEphos catalyst systems, which allows for the selective synthesis of various monoallylamines, such as the biologically active compounds Naftifine and Flunarizine, in good to high yield without need for an activator. The choice of the ligand was crucial toward achieving high catalytic activity, and we demonstrated that not only the large bite-angle but also the linker oxygen atom of the Xantphos and DPEphos ligands was highly important. In addition, microwave heating dramatically affected the catalyst activity and considerably decreased the reaction time compared with conventional heating. Furthermore, several mechanistic investigations, including 1H and 31P{1H} NMR studies; isolation and characterization of several catalytic intermediates, Pt(xantphos)Cl2, Pt(η2-C3H5OH)(xantphos), etc; confirmation of the structure of [Pt(η3-allyl)(xantphos)]OTf by X-ray crystallographic analysis; and crossover experiments, suggested that formation of the π-allylplatinum complex through the elimination of water is an irreversible rate-determining step and that the other processes in the catalytic cycle are reversible, even at room temperature.
