40227-54-1

Upstream product

• 18393-54-9 2-methyl-2,3-dihydro-phthalazine-1,4-dione 
• 2257-69-4 1-chloro-4-phthalazinone 
• 77-78-1 dimethyl sulfate 
• 87878-21-5 1-(4-nitrophenyl)-3-phenyl-5-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)-3-phenylformazan EE'E'' form 
• 85093-49-8 2-(4-nitrophenyl)-4-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)benzohydrazidine 
• 74-88-4 methyl iodide 
• 85-44-9 phthalic anhydride 
• 64640-64-8 2-methyl-4-chloro-1-phthalazinone hydrazone 
• 87878-22-6 2-phenyl-4-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)benzohydrazidine 
• 87878-20-4 1,3-diphenyl-5-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)formazan EE'E'' form 

Downstream Products

• 109446-98-2 sulfanilic acid-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-ylamide) 
• 111297-94-0 N-acetyl-sulfanilic acid-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-ylamide) 

Relevant academic research and scientific papers

PHTHALAZINE DERIVATIVES OF FORMULA (I) AS PCAF AND GCN5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER

The present invention relates to methods for treating PCAF and GCN5 mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein ring A, R1, R3, R4, R5, and each Re have any of the values defined in the specification. Also included are novel compounds of Formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Rhodium(III)-Catalyzed C-H Functionalization of 1-(2H)-Phthalazinones at C8

The rhodium(III) catalyst tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate ([Cp*Rh(MeCN)3](SbF6)2) reacts with 1-(2H)-phthalazinones to promote a C-H functionalization event at C8. Preparation

Study on ferrocenes, Part 6.* Synthesis and structure of ferrocenylmethylidenehydrazino-phthalazinones and -pyrido[2,3-d]pyridazinones

Hydrazinophthalazinones and -pyrido[2,3-d]pyridazinones 3a-j easily underwent a stereoselective condensation reaction with formylferrocene (1a) to give hydrazones 4a-j of E configuration. In much slower conversions acetylferrocene (1b) only condensed with hydrazinophthalazinones 3b,c yielding hydrazones 5b as a mixture of E/Z isomers and 5c purely in E form, respectively. The stereostructure of products was proved by IR, 1D- and 2D-NMR methods and for 4b,j by X-ray analysis.

HYDRAZONES OF PHTHALAZONES. SOME FORMAZANS AND HYDRAZIDINES

In formazans, isolated during the azo coupling of arenediazonium salts with benzylidenehydrazones of 4-chloro-1-phthalazinone, the hydrogen atom is localized at the nitrogen atom of the ring and not in the formazan fragment.These formazans and their analo

AMINOPHTHALAZINONE DERIVATIVES, VII REACTION OF CHLOROPHTHALAZINONE WITH SECONDARY AMINES STUDY OF THE STERIC EFFECT, II

In the aminolysis of chlorophthalazinone (1a) with secondary amines, the yield of N-substitution (1 5, 1 7) is significantly affected by the steric structure of the amine.In the cyclic secondary amines substituents at the C-2 position give rise to a strong steric hindrance.The possibility for N-substitution gradually decreases with increasing size of the ring, while in the case of open-chain secondary amines it varies suddenly as a function of the position of the NH group in the chain.