40227-86-9

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 6622-92-0 4-hydroxy 2,6-dimethylpyrimidine 

Downstream Products

• 1191954-67-2 4-cyclohexyl-2,6-dimethylpyrimidine 
• 1285695-09-1 N-cyclohexyl-2,6-dimethylpyrimidine-4-carboxamide 
• 1233503-36-0 (R)-benzyl 1-(2,6-dimethylpyrimidin-4-yl)-4-oxoazetidine-2-carboxylate 
• 1233503-39-3 benzyl 2,6-dimethylpyrimidin-4-ylcarbamate 
• 1233503-47-3 3-(1-(2,6-dimethylpyrimidin-4-yl)-3-phenyl-1H-indol-2-yl)oxazolidin-2-one 

Relevant academic research and scientific papers

Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives

Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki-Miyaura cross-coupling of the prepared tosylates with phenylboronic acid.

Heteroaromatic tosylates as electrophiles in regioselective Mizoroki-Heck-coupling reactions with electron-rich olefins

Heteroaromatic 2-pyridyl tosylates were successfully applied as electrophiles in palladium(0)-catalyzed Mizoroki-Heck-coupling reactions to electron-rich olefins with complete aregioselectivity. This protocol represents a general strategy for the application of pyridyl tosylates and mesylates in the Mizoroki-Heck coupling. The catalytic system also proved adaptable to changes in the heteroaromatic core as well as large-scale applications. Finally, the synthetic utility of the functionalized α-heteroarylvinyl amides was established providing straightforward access to highly functionalized heteroaromatic compounds including chiral benzylic amide derivatives.