40230-93-1

Basic information

• Product Name: 1-((TRIMETHYLSILYL)ETHYNYL)-3-TRIFLUORO&
• Synonyms: 1-((TRIMETHYLSILYL)ETHYNYL)-3-TRIFLUORO&;TRIMETHYL-(3-TRIFLUOROMETHYL-PHENYLETHYNYL)-SILANE;1-(3'-trifluoromethylphenyl)-2-(trimethylsilyl)acetylene;1-[(Trimethylsilyl)ethynyl]-3-(trifluoromethyl)benzene 98%
• CAS NO: 40230-93-1
• Molecular Formula: C₁₂H₁₃F₃Si
• Molecular Weight: 242.3123296
• Mol File: 40230-93-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 50-52 °C0.5 mm Hg(lit.)
• Flash Point: 185 °F
• Appearance: /
• Density: 1.036 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.144mmHg at 25°C
• Refractive Index: n20/D 1.4760(lit.)
• CAS DataBase Reference: 1-((TRIMETHYLSILYL)ETHYNYL)-3-TRIFLUORO&(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((TRIMETHYLSILYL)ETHYNYL)-3-TRIFLUORO&(40230-93-1)
• EPA Substance Registry System: 1-((TRIMETHYLSILYL)ETHYNYL)-3-TRIFLUORO&(40230-93-1)

Safety Data

• Safety Statements: 24/25
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 40230-93-1(Hazardous Substances Data)

Usage

General Description

1-((Trimethylsilyl)ethynyl)-3-trifluoromethylbenzene, also known as TMS phenylacetylene, is a chemical compound with the molecular formula C10H9F3Si. It is a colorless liquid that is used in organic synthesis and as a building block in the production of various pharmaceuticals and agrochemicals. TMS phenylacetylene is a versatile reagent in the field of chemistry, particularly in the preparation of functionalized organosilicon compounds. It is also used as a protective group in the synthesis of complex organic molecules, due to its ability to be easily removed under mild conditions. The compound is considered to be relatively stable and has low reactivity, making it a valuable tool in the field of organic chemistry.

InChI:InChI=1/C12H13F3Si/c1-16(2,3)8-7-10-5-4-6-11(9-10)12(13,14)15/h4-6,9H,1-3H3

Upstream product

• 401-81-0 m-trifluoromethylphenyl iodide 
• 1066-54-2 trimethylsilylacetylene 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Downstream Products

• 150969-56-5 5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 1402355-04-7 (E)-1-(1-bromo-3-phenylbut-1-enyl)-3-(trifluoromethyl)benzene 
• 1402355-05-8 (Z)-1-(1-bromo-3-phenylbut-1-enyl)-3-(trifluoromethyl)benzene 
• 1119624-22-4 (4-acetylphenyl)(3-trifluoromethylphenyl)ethyne 
• 869578-02-9 (4-cyanophenyl)(3-trifluoromethylphenyl)ethyne 
• 1119624-23-5 2-((3-(trifluoromethyl)phenyl)ethynyl)pyridine 
• 866684-68-6 5-(3-trifluoromethylphenylethynyl)-nicotinonitrile 

Relevant articles and documents

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Hydroxy-cruciforms

The synthesis of hydroxy-cruciforms 7 and 8 and their dramatically varying photophysical properties upon exposure to amines are reported. The Royal Society of Chemistry.