40230-93-1

Usage

Uses

Used in Organic Synthesis:
TMS phenylacetylene is used as a building block in the production of various pharmaceuticals and agrochemicals. Its unique properties and versatility make it an essential component in the synthesis of a wide range of compounds.
Used in the Preparation of Organosilicon Compounds:
TMS phenylacetylene is utilized in the preparation of functionalized organosilicon compounds, which have a broad range of applications in the chemical industry, including the development of new materials and the improvement of existing ones.
Used as a Protective Group in Complex Organic Molecule Synthesis:
Due to its ability to be easily removed under mild conditions, TMS phenylacetylene is used as a protective group in the synthesis of complex organic molecules. This feature allows chemists to control the reactivity of certain functional groups during the synthesis process, leading to more efficient and selective reactions.
Used in Pharmaceutical and Agrochemical Production:
TMS phenylacetylene plays a crucial role in the production of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and the improvement of existing ones. Its use in this industry highlights its importance in the field of organic chemistry and its potential impact on human health and agriculture.

InChI:InChI=1/C12H13F3Si/c1-16(2,3)8-7-10-5-4-6-11(9-10)12(13,14)15/h4-6,9H,1-3H3

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 1066-54-2 trimethylsilylacetylene 
• 401-81-0 m-trifluoromethylphenyl iodide 

Downstream Products

• 705-28-2 1-ethynyl-3-trifluoromethylbenzene 
• 150969-56-5 5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one 
• 944250-16-2 C₅₀H₄₀O₄F₆ 
• 866684-68-6 5-(3-trifluoromethylphenylethynyl)-nicotinonitrile 
• 1119624-23-5 2-((3-(trifluoromethyl)phenyl)ethynyl)pyridine 
• 869578-02-9 (4-cyanophenyl)(3-trifluoromethylphenyl)ethyne 
• 1119624-22-4 (4-acetylphenyl)(3-trifluoromethylphenyl)ethyne 
• 1402355-04-7 (E)-1-(1-bromo-3-phenylbut-1-enyl)-3-(trifluoromethyl)benzene 
• 1402355-05-8 (Z)-1-(1-bromo-3-phenylbut-1-enyl)-3-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

Regioselective Gold-Catalyzed Hydration of CF3- and SF5-alkynes

The regioselective gold-catalyzed hydration of CF3- and SF5-alkynes is described. The corresponding trifluoromethylated and pentasulfanylated ketones are obtained in up to 91% yield as single regioisomers showcasing the use of CF3 and SF5 as highly efficient directing groups in this reaction. Notably, this transformation represents the first use of CF3- and SF5-alkynes in gold catalysis.

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Stereodivergent zinc-mediated three-component synthesis of tri- and tetrasubstituted alkenes

Zinc simple: The loading-dependent zinc-mediated addition of benzyl bromides to alkynes is the key step for the formation of vinyl bromides. In combination with a palladium-catalyzed Suzuki cross-coupling reaction with boronic acids, tri- and tetrasubstit

Hydroxy-cruciforms

The synthesis of hydroxy-cruciforms 7 and 8 and their dramatically varying photophysical properties upon exposure to amines are reported. The Royal Society of Chemistry.

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.

Palladium-catalyzed carbon-carbon coupling reactions using aryl Grignards

Coupling reactions using Pd(PPh3)4 were investigated with a number of electron donating and electron withdrawing substituents. High yields were obtained with both types of substituents. In competitive reactions the electron-withdrawi

Facile Synthesis of Ethynylated Benzoic Acid Derivatives and Aromatic Compounds via Ethynyltrimethylsilane

The coupling reaction between an aromatic halide and ethynyltrimethylsilane under the catalysis of palladium(0) generated in situ, followed by treatment of the (trimethylsilyl)ethynyl product with potassium carbonate in methanol at ambient temperatures, provides a simple approach to various ethynylated benzoic acid derivatives and other aromatic compounds.The conditions for the removal of the trimethylsilyl group were very mild, so that base-sensitive functionalities on the aromatic moiety could be tolerated.